Defective B cell response to TLR9 ligand (CpG-ODN), Streptococcus pneumoniae and Haemophilus influenzae extracts in common variable immunodeficiency patients

Danilo Escobar, Jaime Pons, Antonio Clemente, Julio Iglesias, Verónica Regueiro, José A Bengoechea, Nuria Matamoros, Joana M Ferrer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinaemia and antibody deficiency to both T dependent and independent antigens. Patients suffer from recurrent sinopulmonary infections mostly caused by Streptococcus pneumoniae and Haemophilus influenzae, but also gastrointestinal or autoimmune symptoms. Their response to vaccination is poor or absent. In this study we investigated B cell activation induced by the TLR9 specific ligand (CpG-ODN) and bacterial extracts from S. pneumoniae and H. influenzae known to stimulate several TLR. We found that B cells from CVID patients express lower levels of CD86 after stimulation with CpG-ODN, S. pneumoniae and H. influenzae extracts in combination with anti-IgM antibody and also display a lower proliferative index when stimulated with bacterial extracts. Our results point to a broad TLR signalling defect in B lymphocytes from CVID patients that may be related to the hypogammaglobulinaemia and poor response to vaccination characteristic of these patients.
Original languageEnglish
Pages (from-to)105-11
Number of pages7
JournalCellular immunology
Volume262
Issue number2
DOIs
Publication statusPublished - 2010

Bibliographical note

Copyright 2010 Elsevier Inc. All rights reserved.

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