Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Khuloud T Al-Jamal, Antonio Nunes, Laura Methven, Hanene Ali-Boucetta, Shouping Li, Francesca M Toma, M Antonia Herrero, Wafa' T Al-Jamal, Huub M M ten Eikelder, Julie Foster, Stephen Mather, Maurizio Prato, Alberto Bianco, Kostas Kostarelos

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

Original languageEnglish
Pages (from-to)6389-93
Number of pages5
JournalAngewandte Chemie (International ed. in English)
Volume51
Issue number26
DOIs
Publication statusPublished - 25 Jun 2012

Keywords

  • Amines
  • Animals
  • Mice
  • Microscopy, Electron, Transmission
  • Models, Molecular
  • Molecular Structure
  • Nanotubes, Carbon
  • Organ Specificity
  • Journal Article
  • Research Support, Non-U.S. Gov't

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  • Cite this

    Al-Jamal, K. T., Nunes, A., Methven, L., Ali-Boucetta, H., Li, S., Toma, F. M., Herrero, M. A., Al-Jamal, W. T., ten Eikelder, H. M. M., Foster, J., Mather, S., Prato, M., Bianco, A., & Kostarelos, K. (2012). Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile. Angewandte Chemie (International ed. in English), 51(26), 6389-93. https://doi.org/10.1002/anie.201201991