Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3 beta?

R.M. Carew, M. Sadagurski, R. Goldschmeding, F. Martin, M.F. White, Derek Brazil

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
13 Downloads (Pure)

Abstract

Background: Male Irs2(-/-) mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2(-/-) mice. We identify retarded renal growth in male and female Irs2(-/-) mice, independent of diabetes.
Original languageEnglish
Article number73
Number of pages8
JournalBMC Developmental Biology
Volume10
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Developmental Biology

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