Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3 beta?

R.M. Carew; M. Sadagurski; R. Goldschmeding; F. Martin; M.F. White; Derek Brazil

doi:10.1186/1471-213X-10-73

Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3 beta?

R.M. Carew
, M. Sadagurski
, R. Goldschmeding
, F. Martin
, M.F. White
, Derek Brazil

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

33 Downloads (Pure)

Abstract

Background: Male Irs2(-/-) mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2(-/-) mice. We identify retarded renal growth in male and female Irs2(-/-) mice, independent of diabetes.

Original language	English
Article number	73
Number of pages	8
Journal	BMC Developmental Biology
Volume	10
DOIs	https://doi.org/10.1186/1471-213X-10-73
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Developmental Biology

Access to Document

10.1186/1471-213X-10-73Licence: CC BY

Research article Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3β?
© 2010 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.07 MBLicence: CC BY

Cite this

@article{c5e279c177074224b61347784e48a41e,

title = "Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3 beta?",

abstract = "Background: Male Irs2(-/-) mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2(-/-) mice. We identify retarded renal growth in male and female Irs2(-/-) mice, independent of diabetes.",

author = "R.M. Carew and M. Sadagurski and R. Goldschmeding and F. Martin and M.F. White and Derek Brazil",

year = "2010",

doi = "10.1186/1471-213X-10-73",

language = "English",

volume = "10",

journal = "BMC Developmental Biology",