Delivery of nucleic acids for cancer gene therapy: overcoming extra- and intra-cellular barriers

Research output: Contribution to journalReview article

10 Citations (Scopus)
182 Downloads (Pure)

Abstract

The therapeutic potential of cancer gene therapy has been limited by the difficulty of delivering genetic material to target sites. Various biological and molecular barriers exist which need to be overcome before effective nonviral delivery systems can be applied successfully in oncology. Herein, various barriers are described and strategies to circumvent such obstacles are discussed, considering both the extracellular and intracellular setting. Development of multifunctional delivery systems holds much promise for the progression of gene delivery, and a growing body of evidence supports this approach involving rational design of vectors, with a unique molecular architecture. In addition, the potential application of composite gene delivery platforms is highlighted which may provide an alternative delivery strategy to traditional systemic administration.

Original languageEnglish
Pages (from-to)619-37
Number of pages19
JournalTherapeutic Delivery
Volume7
Issue number9
DOIs
Publication statusPublished - 01 Sep 2016

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Neoplasm Genes
Genetic Therapy
Nucleic Acids
Genes
Therapeutics

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title = "Delivery of nucleic acids for cancer gene therapy: overcoming extra- and intra-cellular barriers",
abstract = "The therapeutic potential of cancer gene therapy has been limited by the difficulty of delivering genetic material to target sites. Various biological and molecular barriers exist which need to be overcome before effective nonviral delivery systems can be applied successfully in oncology. Herein, various barriers are described and strategies to circumvent such obstacles are discussed, considering both the extracellular and intracellular setting. Development of multifunctional delivery systems holds much promise for the progression of gene delivery, and a growing body of evidence supports this approach involving rational design of vectors, with a unique molecular architecture. In addition, the potential application of composite gene delivery platforms is highlighted which may provide an alternative delivery strategy to traditional systemic administration.",
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Delivery of nucleic acids for cancer gene therapy: overcoming extra- and intra-cellular barriers. / McErlean, Emma M; McCrudden, Cian M; McCarthy, Helen O.

In: Therapeutic Delivery, Vol. 7, No. 9, 01.09.2016, p. 619-37.

Research output: Contribution to journalReview article

TY - JOUR

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AU - McErlean, Emma M

AU - McCrudden, Cian M

AU - McCarthy, Helen O

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N2 - The therapeutic potential of cancer gene therapy has been limited by the difficulty of delivering genetic material to target sites. Various biological and molecular barriers exist which need to be overcome before effective nonviral delivery systems can be applied successfully in oncology. Herein, various barriers are described and strategies to circumvent such obstacles are discussed, considering both the extracellular and intracellular setting. Development of multifunctional delivery systems holds much promise for the progression of gene delivery, and a growing body of evidence supports this approach involving rational design of vectors, with a unique molecular architecture. In addition, the potential application of composite gene delivery platforms is highlighted which may provide an alternative delivery strategy to traditional systemic administration.

AB - The therapeutic potential of cancer gene therapy has been limited by the difficulty of delivering genetic material to target sites. Various biological and molecular barriers exist which need to be overcome before effective nonviral delivery systems can be applied successfully in oncology. Herein, various barriers are described and strategies to circumvent such obstacles are discussed, considering both the extracellular and intracellular setting. Development of multifunctional delivery systems holds much promise for the progression of gene delivery, and a growing body of evidence supports this approach involving rational design of vectors, with a unique molecular architecture. In addition, the potential application of composite gene delivery platforms is highlighted which may provide an alternative delivery strategy to traditional systemic administration.

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DO - 10.4155/tde-2016-0049

M3 - Review article

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EP - 637

JO - Therapeutic Delivery

JF - Therapeutic Delivery

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