Abstract
Increases in free light chain (FLC) production are associated with disease progression in multiple myeloma (MM). Using a double immunofluorescence staining method to produce a differential count of plasma cells in bone marrow, single populations were demonstrated, containing intact monoclonal immunoglobulins (M-Igs) in 74% and FLCs only in 8% of cases. However, 18% contained a mixture of both cell populations. Progression from cells making intact M-Ig to cells restricted to FLC only production occurred in individual cases during the course of their disease. The presence of FLC only cells was associated with shortened survival.
| Original language | English |
|---|---|
| Pages (from-to) | 1135-1138 |
| Number of pages | 4 |
| Journal | HAEMATOLOGICA |
| Volume | 92 |
| Issue number | 8 |
| Publication status | Published - Aug 2007 |
Keywords
- Adult
- Aged
- Amyloidosis
- Bone Marrow
- Cell Count
- Disease Progression
- Female
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Leukemia, Plasma Cell
- Male
- Microscopy, Fluorescence
- Middle Aged
- Multiple Myeloma
- Myeloma Proteins
- Paraproteinemias
- Plasma Cells
- Plasmacytoma
- Retrospective Studies
- Waldenstrom Macroglobulinemia
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Cite this
Ayliffe, M. J., Davies, F. E., de Castro, D., & Morgan, G. J. (2007). Demonstration of changes in plasma cell subsets in multiple myeloma. HAEMATOLOGICA, 92(8), 1135-1138. http://www.ncbi.nlm.nih.gov/pubmed/17650446