Denaturing high performance liquid chromatography for the detection of microsatellite instability using Bethesda and pentaplex marker panels

R. Soong, D. Amar, Y.Q. Liu, K.W. Eu, H.C. Han, Manuel Salto-Tellez, B. Iacopetta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Microsatellite instability (MSI) is a characteristic molecular phenotype of tumors from the hereditary nonpolyposis colorectal cancer (Lynch) syndrome. Routine MSI screening of tumors in patients is an efficient prescreening tool for the population-based detection of Lynch syndrome in the absence of family cancer history. We describe here the optimization of a denaturing high performance liquid chromatography (DHPLC) assay for MSI analysis with the
Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalDiagnostic Molecular Pathology
Volume17
Issue number3
Publication statusPublished - Sep 2008

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)
  • Pathology and Forensic Medicine

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