Dental fluorosis and oral health in the African Esophageal Cancer Corridor: Findings from the Kenya ESCCAPE case–control study and a pan-African perspective

Diana Menya, Stephen K. Maina, Caroline Kibosia, Nicholas Kigen, Margaret Oduor, Fatma Some, David Chumba, Paul Ayuo, Daniel R.S. Middleton, Odipo Osano, Behnoush Abedi-Ardekani, Joachim Schüz, Valerie A. McCormack*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
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Abstract

There are no studies of oral health in relation to esophageal cancer in Africa, or of Eastern Africa's endemic dental fluorosis, an irreversible enamel hypo-mineralization due to early-life excessive fluoride intake. During 2014–18, we conducted a case–control study of squamous cell esophageal cancer in Eldoret, western Kenya. Odds ratios (AORs (95% confidence intervals)) were adjusted for design factors, tobacco, alcohol, ethnicity, education, oral hygiene and missing/decayed teeth. Esophageal cancer cases (N = 430) had poorer oral health and hygiene than controls (N = 440). Compared to no dental fluorosis, moderate/severe fluorosis, which affected 44% of cases, had a crude OR of 20.8 (11.6, 37.4) and on full adjustment was associated with 9.4-fold (4.6, 19.1) increased risk, whilst mild fluorosis (43% of cases) had an AOR of 2.3 (1.3, 4.0). The prevalence of oral leukoplakia and tooth loss/decay increased with fluorosis severity, and increased cancer risks associated with moderate/severe fluorosis were particularly strong in individuals with more tooth loss/decay. Using a mswaki stick (AOR = 1.7 (1.0, 2.9)) rather than a commercial tooth brush and infrequent tooth brushing also independently increased risk. Geographic variations showed that areas of high esophageal cancer incidence and those of high groundwater fluoride levels have remarkably similar locations across Eastern Africa. In conclusion, poor oral health in combination with, or as a result of, high-altitude susceptibility to hydro-geologically influenced dental fluorosis may underlie the striking co-location of Africa's esophageal cancer corridor with the Rift Valley. The findings call for heightened research into primary prevention opportunities of this highly fatal but common cancer.

Original languageEnglish
Pages (from-to)99-109
Number of pages11
JournalInternational Journal of Cancer
Volume145
Issue number1
Early online date12 Jan 2019
DOIs
Publication statusPublished - 01 Jul 2019
Externally publishedYes

Bibliographical note

Funding Information:
We express our thanks to the participants in this case?control study for their support and time. This work was supported by the International Agency for Research on Cancer (IARC), NIH/NCI grant R21CA191965, an IARC-UICC Development Fellowship to SKM and an IARC post-doctoral fellowship to DM partially supported by the European Commission FP7 Marie Curie Actions ? People ? Co-funding of regional, national and international programs (COFUND).

Publisher Copyright:
© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC

Keywords

  • Africa
  • cancer
  • dental fluorosis
  • esophageal cancer
  • oral health

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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