Deoxynivalenol exposure assessment in young children in Tanzania

Chou Srey, Martin E. Kimanya, Michael N. Routledge, Candida P. Shirima, Yun Yun Gong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Scope: This study assessed deoxynivalenol (DON) exposure in children from three geographic locations within Tanzania, over three time points in 1 year, using a urinary biomarker of exposure.

Methods and results: A total of 166 children aged 6-14 months were studied at a maize harvest and followed up twice at 6-month intervals. On two consecutive days, morning urine was collected from each child and urinary DON was measured using an LC-MS method, with and without beta-glucuronidase hydrolysis in order to assess free DON (fDON) and glucuronide DON. Overall, urinary DON increased significantly along with the three visits (geometric mean 1.1, 2.3, and 5.7 ng/mL, at visits 1, 2, and 3, respectively, p <0.01). fDON was 22% of urinary total DON. Urinary DON excretion rate was 74% in village Kikelelwa based on food DON level and food consumption. Assuming 360 mL of urine excreted per day, 10, 19, and 29% of children at visits 1, 2, and 3, respectively, exceeded the provisional maximum tolerable daily intake of 1000 ng/kg b.w./day.

Conclusion: Young children in Tanzania are chronically exposed to DON due to eating contaminated maize, although exposure levels varied markedly by region and season.

Original languageEnglish
Pages (from-to)1574-1580
Number of pages7
JournalMolecular Nutrition & Food Research
Volume58
Issue number7
Early online date14 May 2014
DOIs
Publication statusPublished - Jul 2014

Bibliographical note

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

  • Biomarkers
  • Children
  • Deoxynivalenol
  • Exposure assessment
  • FRENCH TOTAL DIET
  • URINARY DEOXYNIVALENOL
  • UK ADULTS
  • CONTAMINATED WHEAT
  • FATTENING PIGS
  • EXCRETION
  • WOMEN
  • MYCOTOXINS
  • BIOMARKERS
  • AFLATOXIN

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