Dependence on Dectin-1 Varies With Multiple Candida Species

Aiysha Thompson, James S. Griffiths, Louise Walker, Diogo M. da Fonseca, Keunsook K. Lee, Philip R. Taylor, Neil A.R. Gow, Selinda J. Orr*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
34 Downloads (Pure)


Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C. glabrata, however, whether Dectin-1 is important for host defense against C. tropicalis or C. parapsilosis is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse Candida spp. We found that Dectin-1 mediates innate cytokine responses to these Candida spp. in a species-and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent C. albicans while they mostly survived infection with less virulent Candida spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each Candida spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple Candida spp., although the specific roles for Dectin-1 varies with different Candida spp.

Original languageEnglish
Article number1800
JournalFrontiers in Microbiology
Publication statusPublished - 06 Aug 2019

Bibliographical note

Funding Information:
SO was funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 099953/Z/12/Z) and by a Wellcome Trust Cross-Disciplinary Award. PT is supported by a Wellcome Trust Investigator Award (107964/Z/15/Z) and the UK Dementia Research Institute. NG was supported by the Wellcome Trust Investigator, Collaborative, Equipment, Strategic and Biomedical Resource awards (086827, 075470, 097377, 101873, 200208, 093378, and 099197), and by the MRC Centre for Medical Mycology (N006364/1).

Publisher Copyright:
© 2019 Thompson, Griffiths, Walker, da Fonseca, Lee, Taylor, Gow and Orr.

Copyright 2019 Elsevier B.V., All rights reserved.


  • Candida spp
  • Dectin-1
  • Dendritic cells
  • Macrophages
  • T cells

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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