Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection

Aiysha Thompson, Diogo M da Fonseca, Louise Walker, James S Griffiths, Philip R Taylor, Neil A R Gow, Selinda J Orr

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Abstract

More than 95% of invasive infections are caused by four spp. ( ). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to . Dectin-1 promotes clearance of , and , however, dependence on Dectin-1 for specific immune responses varies with the different spp. Dectin-2 is important for host immunity to and , and Mincle is important for the immune response to However, whether Dectin-2 drives host immunity to or , and whether Mincle mediates host immunity to or is unknown. Therefore, we compared the roles of Dectin-2 and Mincle in response to these four spp. We demonstrate that these four spp. cell walls have differential mannan contents. Mincle and Dectin-2 play a key role in regulating cytokine production in response to these four spp. and Dectin-2 is also important for clearance of all four spp. during systemic infection. However, Mincle was only important for clearance of during systemic infection. Our data indicate that multiple spp. have different mannan contents, and dependence on the mannan-detecting CLRs, Mincle, and Dectin-2 varies between different spp. during systemic infection. [Abstract copyright: Copyright © 2021 Thompson, da Fonseca, Walker, Griffiths, Taylor, Gow and Orr.]
Original languageEnglish
Pages (from-to)633229
JournalFrontiers in Microbiology
Volume12
Early online date25 Feb 2021
DOIs
Publication statusPublished - 25 Feb 2021

Keywords

  • CLR
  • Candida
  • Dectin-2
  • Mincle
  • fungal

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