Derivation and Application of Molecular Signatures to Prostate Cancer: Opportunities and Challenges

Dimitrios Doultsinos, Ian G. Mills

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Abstract

Prostate cancer is a high-incidence cancer that requires improved patient stratification to ensure accurate predictions of risk and treatment response. Due to the significant contributions of transcription factors and epigenetic regulators to prostate cancer progression, there has been considerable progress made in developing gene signatures that may achieve this. Some of these are aligned to activities of key drivers such as the androgen receptor, whilst others are more agnostic. In this review, we present an overview of these signatures, the strategies for their derivation, and future perspectives on their continued development and evolution.
Original languageEnglish
Article number495
Number of pages25
JournalCancers
Volume13
Issue number3
DOIs
Publication statusPublished - 28 Jan 2021

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