Design, development, and technical considerations for dry powder inhaler devices

Sagar Dhoble, Archana Kapse, Vaibhav Ghegade, Manasi Chogale, Vinod Ghodake, Vandana Patravale*, Lalitkumar K. Vora*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

The dry powder inhaler (DPI) stands out as a highly patient-friendly and effective pulmonary formulation, surpassing traditional and other pulmonary dosage forms in certain disease conditions. The development of DPI products, however, presents more complexities than that of other dosage forms, particularly in device design and the integration of the drug formulation. This review focuses on the capabilities of DPI devices in pulmonary drug delivery, with a special emphasis on device design and formulation development. It also discusses into the principles of deep lung particle deposition and device engineering, and provides a current overview of the market for DPI devices. Furthermore, the review highlights the use of computational fluid dynamics (CFD) in DPI product design and discusses the regulatory environment surrounding these devices.

Original languageEnglish
Article number103954
Number of pages12
JournalDrug Discovery Today
Volume29
Issue number5
Early online date04 Apr 2024
DOIs
Publication statusPublished - May 2024

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