Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

A Skytthe; S Valensin; B Jeune; E Cevenini; F Balard; M Beekman; V Bezrukov; H Blanche; L Bolund; K Broczek; C Carru; K Christensen; L Christiansen; J C Collerton; R Cotichini; A J M de Craen; S Dato; K Davies; G De Benedictis; L Deiana; F Flachsbart; J Gampe; C Gilbault; E S Gonos; E Haimes; A Hervonen; M A Hurme; D Janiszewska; M Jylhä; T B L Kirkwood; P Kristensen; P Laiho; A Leon; A Marchisio; R Masciulli; A Nebel; G Passarino; G Pelicci; L Peltonen; M Perola; M Poulain; I M Rea; J Remacle; J M Robine; S Schreiber; M Scurti; F Sevini; E Sikora; A Skouteri; P E Slagboom; GEHA consortium

doi:10.1016/j.exger.2011.08.005

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

A Skytthe
, S Valensin
, B Jeune
, E Cevenini
, F Balard
, M Beekman
, V Bezrukov
, H Blanche
, L Bolund
, K Broczek
, C Carru
, K Christensen
, L Christiansen
, J C Collerton
, R Cotichini
, A J M de Craen
, S Dato
, K Davies
, G De Benedictis
, L Deiana

F Flachsbart, J Gampe, C Gilbault, E S Gonos, E Haimes, A Hervonen, M A Hurme, D Janiszewska, M Jylhä, T B L Kirkwood, P Kristensen, P Laiho, A Leon, A Marchisio, R Masciulli, A Nebel, G Passarino, G Pelicci, L Peltonen, M Perola, M Poulain, I M Rea, J Remacle, J M Robine, S Schreiber, M Scurti, F Sevini, E Sikora, A Skouteri, P E Slagboom, GEHA consortium

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.

Original language	English
Pages (from-to)	934-45
Number of pages	12
Journal	Experimental Gerontology
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.exger.2011.08.005
Publication status	Published - Nov 2011

Bibliographical note

ASJC Scopus subject areas

Ageing
Biochemistry
Cell Biology
Endocrinology
Genetics
Molecular Biology

Access to Document

10.1016/j.exger.2011.08.005

Super Vivere Exhibition (opening event of the Luminate Scotland's Creative Ageing Festival 2013) on the International Day for Elderly People (UN 1991) in Stirling University. Readings from authored book Super Vivere: Reflections on Long Life and Ageing Well (Rea&Rea 2011) and Introductory Lecture about the Science behind the EU funded Genetics of Healthy Ageing (GeHA) project and artist's overview.
Rea, M. (Speaker)
01 Oct 2013 → 31 Oct 2013
Activity: Talk or presentation types › Invited talk

45 Citations
2 Article
1 Other contribution to conference

Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing)
Cevenini, E., Cotichini, R., Stazi, M. A., Toccaceli, V., Palmas, M. G., Capri, M., De Rango, F., Dato, S., Passarino, G., Jeune, B., Franceschi, C., GEHA Project Consortium & Rea, I. M., Apr 2014, In: Age (Dordrecht, Netherlands). 36, 2, p. 949-966 18 p.
Research output: Contribution to journal › Article › peer-review
37 Link opens in a new tab Citations (Scopus)
How to classify the Oldest Old according to Health Status: A study of 1160 subjects belonging to 552 90+ Italian sibships characterised by familial longevity recruited within the GeHA EU project
GEHA Project Consortium, 01 Dec 2013, In: Mechanisms of Ageing and Development. 134, 11-12, p. 560-569 9 p.
Research output: Contribution to journal › Article › peer-review
10 Link opens in a new tab Citations (Scopus)
Nature or Nurture Nonagenarians tell us how they understand their Ageing Long and Ageing Well
Rea, M., 14 Jun 2013, (In preparation).
Research output: Contribution to conference › Other contribution to conference

Cite this

Skytthe, A., Valensin, S., Jeune, B., Cevenini, E., Balard, F., Beekman, M., Bezrukov, V., Blanche, H., Bolund, L., Broczek, K., Carru, C., Christensen, K., Christiansen, L., Collerton, J. C., Cotichini, R., de Craen, A. J. M., Dato, S., Davies, K., De Benedictis, G., ... GEHA consortium (2011). Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Experimental Gerontology, 46(11), 934-45. https://doi.org/10.1016/j.exger.2011.08.005

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abstract = "In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.",

author = "A Skytthe and S Valensin and B Jeune and E Cevenini and F Balard and M Beekman and V Bezrukov and H Blanche and L Bolund and K Broczek and C Carru and K Christensen and L Christiansen and Collerton, \{J C\} and R Cotichini and \{de Craen\}, \{A J M\} and S Dato and K Davies and \{De Benedictis\}, G and L Deiana and F Flachsbart and J Gampe and C Gilbault and Gonos, \{E S\} and E Haimes and A Hervonen and Hurme, \{M A\} and D Janiszewska and M Jylh{\"a} and Kirkwood, \{T B L\} and P Kristensen and P Laiho and A Leon and A Marchisio and R Masciulli and A Nebel and G Passarino and G Pelicci and L Peltonen and M Perola and M Poulain and Rea, \{I M\} and J Remacle and Robine, \{J M\} and S Schreiber and M Scurti and F Sevini and E Sikora and A Skouteri and Slagboom, \{P E\} and \{GEHA consortium\}",

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Skytthe, A, Valensin, S, Jeune, B, Cevenini, E, Balard, F, Beekman, M, Bezrukov, V, Blanche, H, Bolund, L, Broczek, K, Carru, C, Christensen, K, Christiansen, L, Collerton, JC, Cotichini, R, de Craen, AJM, Dato, S, Davies, K, De Benedictis, G, Deiana, L, Flachsbart, F, Gampe, J, Gilbault, C, Gonos, ES, Haimes, E, Hervonen, A, Hurme, MA, Janiszewska, D, Jylhä, M, Kirkwood, TBL, Kristensen, P, Laiho, P, Leon, A, Marchisio, A, Masciulli, R, Nebel, A, Passarino, G, Pelicci, G, Peltonen, L, Perola, M, Poulain, M, Rea, IM, Remacle, J, Robine, JM, Schreiber, S, Scurti, M, Sevini, F, Sikora, E, Skouteri, A, Slagboom, PE & GEHA consortium 2011, 'Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project', Experimental Gerontology, vol. 46, no. 11, pp. 934-45. https://doi.org/10.1016/j.exger.2011.08.005

TY - JOUR

T1 - Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

AU - Skytthe, A

AU - Valensin, S

AU - Jeune, B

AU - Cevenini, E

AU - Balard, F

AU - Beekman, M

AU - Bezrukov, V

AU - Blanche, H

AU - Bolund, L

AU - Broczek, K

AU - Carru, C

AU - Christensen, K

AU - Christiansen, L

AU - Collerton, J C

AU - Cotichini, R

AU - de Craen, A J M

AU - Dato, S

AU - Davies, K

AU - De Benedictis, G

AU - Deiana, L

AU - Flachsbart, F

AU - Gampe, J

AU - Gilbault, C

AU - Gonos, E S

AU - Haimes, E

AU - Hervonen, A

AU - Hurme, M A

AU - Janiszewska, D

AU - Jylhä, M

AU - Kirkwood, T B L

AU - Kristensen, P

AU - Laiho, P

AU - Leon, A

AU - Marchisio, A

AU - Masciulli, R

AU - Nebel, A

AU - Passarino, G

AU - Pelicci, G

AU - Peltonen, L

AU - Perola, M

AU - Poulain, M

AU - Rea, I M

AU - Remacle, J

AU - Robine, J M

AU - Schreiber, S

AU - Scurti, M

AU - Sevini, F

AU - Sikora, E

AU - Skouteri, A

AU - Slagboom, P E

AU - GEHA consortium

PY - 2011/11

Y1 - 2011/11

N2 - In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.

AB - In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.

U2 - 10.1016/j.exger.2011.08.005

DO - 10.1016/j.exger.2011.08.005

M3 - Article

C2 - 21871552

VL - 46

SP - 934

EP - 945

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 11

ER -

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Fingerprint

Activities

Research output

Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing)

How to classify the Oldest Old according to Health Status: A study of 1160 subjects belonging to 552 90+ Italian sibships characterised by familial longevity recruited within the GeHA EU project

Nature or Nurture Nonagenarians tell us how they understand their Ageing Long and Ageing Well

Cite this