Design, synthesis and photodynamic antimicrobial activity of ruthenium trischelate diimine complexes

R. F. Donnelly, N. C. Fletcher, P. J. McCague, J. Donnelly, P. A. McCarron, M. M. Tunney

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)(3)]Cl-2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.
Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalLETTERS IN DRUG DESIGN & DISCOVERY
Volume4
Issue number3
DOIs
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

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