Design, synthesis and photodynamic antimicrobial activity of ruthenium trischelate diimine complexes

R. F. Donnelly; N. C. Fletcher; P. J. McCague; J. Donnelly; P. A. McCarron; M. M. Tunney

doi:10.2174/157018007780077390

Design, synthesis and photodynamic antimicrobial activity of ruthenium trischelate diimine complexes

R. F. Donnelly, N. C. Fletcher, P. J. McCague, J. Donnelly, P. A. McCarron, M. M. Tunney

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)(3)]Cl-2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.

Original language	English
Pages (from-to)	175-179
Number of pages	5
Journal	Letters in Drug Design & Discovery
Volume	4
Issue number	3
DOIs	https://doi.org/10.2174/157018007780077390
Publication status	Published - Apr 2007

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Molecular Medicine

Access to Document

10.2174/157018007780077390

Cite this

@article{c9b13dd483e1497ca7f63a60028e2acc,

title = "Design, synthesis and photodynamic antimicrobial activity of ruthenium trischelate diimine complexes",

abstract = "In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)(3)]Cl-2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.",

author = "Donnelly, {R. F.} and Fletcher, {N. C.} and McCague, {P. J.} and J. Donnelly and McCarron, {P. A.} and Tunney, {M. M.}",

year = "2007",

month = apr,

doi = "10.2174/157018007780077390",

language = "English",

volume = "4",

pages = "175--179",

journal = "Letters in Drug Design & Discovery",

issn = "1570-1808",

publisher = "Bentham Science Publishers",

number = "3",

}

TY - JOUR

T1 - Design, synthesis and photodynamic antimicrobial activity of ruthenium trischelate diimine complexes

AU - Donnelly, R. F.

AU - Fletcher, N. C.

AU - McCague, P. J.

AU - Donnelly, J.

AU - McCarron, P. A.

AU - Tunney, M. M.

PY - 2007/4

Y1 - 2007/4

N2 - In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)(3)]Cl-2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.

AB - In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)(3)]Cl-2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.

U2 - 10.2174/157018007780077390

DO - 10.2174/157018007780077390

M3 - Article

SN - 1570-1808

VL - 4

SP - 175

EP - 179

JO - Letters in Drug Design & Discovery

JF - Letters in Drug Design & Discovery

IS - 3

ER -

Design, synthesis and photodynamic antimicrobial activity of ruthenium trischelate diimine complexes

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this