cis- (3(cis)) and trans-2-(tetradec-5'-enyl)cyclobutanone (3(trans)) have been chemically synthesised and used in the unambiguous identification of the cis isomer 3(cis) in irradiated meat (example chicken) and fruit (example papaya). 11-(2'-Oxocyclobutyl)undecanoic acid 5 has been chemically synthesised, conjugated to bovine thyroglobulin and used to generate polyclonal antibodies in rabbits, which have been used in the development of an enzyme-linked immunosorbent assay for the detection of 2-substituted cyclobutanones in irradiated chicken meat.
|Number of pages||8|
|Journal||Journal of the Chemical Society - Perkin Transactions 1|
|Publication status||Published - 1996|
Hamilton, L., Stevenson, M., Boyd, D., Brannigan, P., Treacy, L., Hamilton, J., McRoberts, R., & Elliott, C. (1996). Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid. Journal of the Chemical Society - Perkin Transactions 1, 45, 139-146.