Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid

Leigh Hamilton, Michael Stevenson, Derek Boyd, Patrick Brannigan, Lisa Treacy, John Hamilton, Robin McRoberts, Christopher Elliott

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

cis- (3(cis)) and trans-2-(tetradec-5'-enyl)cyclobutanone (3(trans)) have been chemically synthesised and used in the unambiguous identification of the cis isomer 3(cis) in irradiated meat (example chicken) and fruit (example papaya). 11-(2'-Oxocyclobutyl)undecanoic acid 5 has been chemically synthesised, conjugated to bovine thyroglobulin and used to generate polyclonal antibodies in rabbits, which have been used in the development of an enzyme-linked immunosorbent assay for the detection of 2-substituted cyclobutanones in irradiated chicken meat.
Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalJournal of the Chemical Society - Perkin Transactions 1
Volume45
Publication statusPublished - 1996

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