Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid

Leigh Hamilton; Michael Stevenson; Derek Boyd; Patrick Brannigan; Lisa Treacy; John Hamilton; Robin McRoberts; Christopher Elliott

Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid

Leigh Hamilton
, Michael Stevenson
, Derek Boyd
, Patrick Brannigan
, Lisa Treacy
, John Hamilton
, Robin McRoberts
, Christopher Elliott

Research output: Contribution to journal › Article › peer-review

Abstract

cis- (3(cis)) and trans-2-(tetradec-5'-enyl)cyclobutanone (3(trans)) have been chemically synthesised and used in the unambiguous identification of the cis isomer 3(cis) in irradiated meat (example chicken) and fruit (example papaya). 11-(2'-Oxocyclobutyl)undecanoic acid 5 has been chemically synthesised, conjugated to bovine thyroglobulin and used to generate polyclonal antibodies in rabbits, which have been used in the development of an enzyme-linked immunosorbent assay for the detection of 2-substituted cyclobutanones in irradiated chicken meat.

Original language	English
Pages (from-to)	139-146
Number of pages	8
Journal	Journal of the Chemical Society - Perkin Transactions 1
Volume	45
Publication status	Published - 1996

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Hamilton, L., Stevenson, M., Boyd, D., Brannigan, P., Treacy, L., Hamilton, J., McRoberts, R., & Elliott, C. (1996). Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid. Journal of the Chemical Society - Perkin Transactions 1, 45, 139-146.

@article{289928965c044c2dbc8260ca6a50e82a,

title = "Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid",

abstract = "cis- (3(cis)) and trans-2-(tetradec-5'-enyl)cyclobutanone (3(trans)) have been chemically synthesised and used in the unambiguous identification of the cis isomer 3(cis) in irradiated meat (example chicken) and fruit (example papaya). 11-(2'-Oxocyclobutyl)undecanoic acid 5 has been chemically synthesised, conjugated to bovine thyroglobulin and used to generate polyclonal antibodies in rabbits, which have been used in the development of an enzyme-linked immunosorbent assay for the detection of 2-substituted cyclobutanones in irradiated chicken meat.",

author = "Leigh Hamilton and Michael Stevenson and Derek Boyd and Patrick Brannigan and Lisa Treacy and John Hamilton and Robin McRoberts and Christopher Elliott",

year = "1996",

language = "English",

volume = "45",

pages = "139--146",

journal = "Journal of the Chemical Society - Perkin Transactions 1",

issn = "1364-5463",

publisher = "Royal Society of Chemistry",

}

Hamilton, L, Stevenson, M, Boyd, D, Brannigan, P, Treacy, L, Hamilton, J, McRoberts, R & Elliott, C 1996, 'Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid', Journal of the Chemical Society - Perkin Transactions 1, vol. 45, pp. 139-146.

Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid. / Hamilton, Leigh; Stevenson, Michael; Boyd, Derek et al.
In: Journal of the Chemical Society - Perkin Transactions 1, Vol. 45, 1996, p. 139-146.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Detection of 2-substituted cyclobutanones as irradiation products of lipid-containing foods: Synthesis and applications of cis- and trans-2-(tetradec-5'-enyl)cyclobutanones and 11-(2'-oxocyclobutyl)-undecanoic acid

AU - Hamilton, Leigh

AU - Stevenson, Michael

AU - Boyd, Derek

AU - Brannigan, Patrick

AU - Treacy, Lisa

AU - Hamilton, John

AU - McRoberts, Robin

AU - Elliott, Christopher

PY - 1996

Y1 - 1996

N2 - cis- (3(cis)) and trans-2-(tetradec-5'-enyl)cyclobutanone (3(trans)) have been chemically synthesised and used in the unambiguous identification of the cis isomer 3(cis) in irradiated meat (example chicken) and fruit (example papaya). 11-(2'-Oxocyclobutyl)undecanoic acid 5 has been chemically synthesised, conjugated to bovine thyroglobulin and used to generate polyclonal antibodies in rabbits, which have been used in the development of an enzyme-linked immunosorbent assay for the detection of 2-substituted cyclobutanones in irradiated chicken meat.

AB - cis- (3(cis)) and trans-2-(tetradec-5'-enyl)cyclobutanone (3(trans)) have been chemically synthesised and used in the unambiguous identification of the cis isomer 3(cis) in irradiated meat (example chicken) and fruit (example papaya). 11-(2'-Oxocyclobutyl)undecanoic acid 5 has been chemically synthesised, conjugated to bovine thyroglobulin and used to generate polyclonal antibodies in rabbits, which have been used in the development of an enzyme-linked immunosorbent assay for the detection of 2-substituted cyclobutanones in irradiated chicken meat.

M3 - Article

SN - 1364-5463

VL - 45

SP - 139

EP - 146

JO - Journal of the Chemical Society - Perkin Transactions 1

JF - Journal of the Chemical Society - Perkin Transactions 1

ER -