Detection of BRAF V600E mutation by pyrosequencing

Y.H. Tan, Y.Q. Liu, K.W. Eu, P.W. Ang, W.Q. Li, Manuel Salto-Tellez, B. Iacopetta, R. Soong

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

Introduction: Detection of the V600E hotspot mutation in BRAF oncogene is extremely useful for the screening of hereditary non-polyposis colorectal cancer (Lynch's syndrome) and for the prediction of sensitivity to MEK inhibitors. Here we describe a method for detecting this mutation based upon pyrosequencing technology.
Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalPathology
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 2008

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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