Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

J.L.H.A. Duprey; Z.Y. Zhao; D.M. Bassani; J. Manchester; Joseph Vyle; J.H.R. Tucker

doi:10.1039/c1cc11205h

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

J.L.H.A. Duprey, Z.Y. Zhao, D.M. Bassani, J. Manchester, Joseph Vyle, J.H.R. Tucker

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.

Original language	English
Pages (from-to)	6629-6631
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	23
DOIs	https://doi.org/10.1039/c1cc11205h
Publication status	Published - 21 Jun 2011

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
Chemistry(all)

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10.1039/c1cc11205h

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title = "Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe",

abstract = "A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.",

author = "J.L.H.A. Duprey and Z.Y. Zhao and D.M. Bassani and J. Manchester and Joseph Vyle and J.H.R. Tucker",

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AU - Manchester, J.

AU - Vyle, Joseph

AU - Tucker, J.H.R.

PY - 2011/6/21

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AB - A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.

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DO - 10.1039/c1cc11205h

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JF - Chemical Communications

SN - 1359-7345

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Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

Abstract

ASJC Scopus subject areas

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