Determinants and dynamics of genome accessibility

Oliver Bell, Vijay K. Tiwari, Nicolas H. Thomä, Dirk Schübeler

Research output: Chapter in Book/Report/Conference proceedingChapter

278 Citations (Scopus)

Abstract

In eukaryotes, all DNA-templated reactions occur in the context of chromatin. Nucleosome packaging inherently restricts DNA accessibility for regulatory proteins but also provides an opportunity to regulate DNA-based processes through modulating nucleosome positions and local chromatin structure. Recent advances in genome-scale methods are yielding increasingly detailed profiles of the genomic distribution of nucleosomes, their modifications and their modifiers. The picture now emerging is one in which the dynamic control of genome accessibility is governed by contributions from DNA sequence, ATP-dependent chromatin remodelling and nucleosome modifications. Here we discuss the interplay of these processes by reviewing our current understanding of how chromatin access contributes to the regulation of transcription, replication and repair.
Original languageEnglish
Title of host publicationNature Reviews Genetics
Pages554-564
Number of pages11
DOIs
Publication statusPublished - Aug 2011

Publication series

NameNature Reviews Genetics
Volume12

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