Determining the minimum clinically important differences for outcomes in the DOMINO trial

Robert Howard, Patrick Phillips, Tony Johnson, John O'Brien, Bart Sheehan, James Lindesay, Peter Bentham, Alistair Burns, Clive Ballard, Clive Holmes, Ian McKeith, Robert Barber, Tom Dening, Craig Ritchie, Rob Jones, Ashley Baldwin, Peter Passmore, David Findlay, Alan Hughes, Ajay MacharouthuSube Banerjee, Roy Jones, Martin Knapp, Richard G Brown, Robin Jacoby, Jessica Adams, Mary Griffin, Richard Gray

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Although less likely to be reported in clinical trials than expressions of the statistical significance of differences in outcomes, whether or not a treatment has delivered a specified minimum clinically important difference (MCID) is also relevant to patients and their caregivers and doctors. Many dementia treatment randomised controlled trials (RCTs) have not reported MCIDs and, where they have been done, observed differences have not reached these.
Original languageEnglish
Pages (from-to)812-7
Number of pages6
JournalInternational Journal of Geriatric Psychiatry
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 2011

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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  • Cite this

    Howard, R., Phillips, P., Johnson, T., O'Brien, J., Sheehan, B., Lindesay, J., Bentham, P., Burns, A., Ballard, C., Holmes, C., McKeith, I., Barber, R., Dening, T., Ritchie, C., Jones, R., Baldwin, A., Passmore, P., Findlay, D., Hughes, A., ... Gray, R. (2011). Determining the minimum clinically important differences for outcomes in the DOMINO trial. International Journal of Geriatric Psychiatry, 26(8), 812-7. https://doi.org/10.1002/gps.2607