Determining the minimum clinically important differences for outcomes in the DOMINO trial

Robert Howard; Patrick Phillips; Tony Johnson; John O'Brien; Bart Sheehan; James Lindesay; Peter Bentham; Alistair Burns; Clive Ballard; Clive Holmes; Ian McKeith; Robert Barber; Tom Dening; Craig Ritchie; Rob Jones; Ashley Baldwin; Peter Passmore; David Findlay; Alan Hughes; Ajay Macharouthu; Sube Banerjee; Roy Jones; Martin Knapp; Richard G Brown; Robin Jacoby; Jessica Adams; Mary Griffin; Richard Gray

doi:10.1002/gps.2607

Determining the minimum clinically important differences for outcomes in the DOMINO trial

Robert Howard, Patrick Phillips, Tony Johnson, John O'Brien, Bart Sheehan, James Lindesay, Peter Bentham, Alistair Burns, Clive Ballard, Clive Holmes, Ian McKeith, Robert Barber, Tom Dening, Craig Ritchie, Rob Jones, Ashley Baldwin, Peter Passmore, David Findlay, Alan Hughes, Ajay MacharouthuSube Banerjee, Roy Jones, Martin Knapp, Richard G Brown, Robin Jacoby, Jessica Adams, Mary Griffin, Richard Gray

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Abstract

Although less likely to be reported in clinical trials than expressions of the statistical significance of differences in outcomes, whether or not a treatment has delivered a specified minimum clinically important difference (MCID) is also relevant to patients and their caregivers and doctors. Many dementia treatment randomised controlled trials (RCTs) have not reported MCIDs and, where they have been done, observed differences have not reached these.

Original language	English
Pages (from-to)	812-7
Number of pages	6
Journal	International Journal of Geriatric Psychiatry
Volume	26
Issue number	8
DOIs	https://doi.org/10.1002/gps.2607
Publication status	Published - Aug 2011

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/gps.2607

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Howard, R., Phillips, P., Johnson, T., O'Brien, J., Sheehan, B., Lindesay, J., Bentham, P., Burns, A., Ballard, C., Holmes, C., McKeith, I., Barber, R., Dening, T., Ritchie, C., Jones, R., Baldwin, A., Passmore, P., Findlay, D., Hughes, A., ... Gray, R. (2011). Determining the minimum clinically important differences for outcomes in the DOMINO trial. International Journal of Geriatric Psychiatry, 26(8), 812-7. https://doi.org/10.1002/gps.2607

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title = "Determining the minimum clinically important differences for outcomes in the DOMINO trial",

abstract = "Although less likely to be reported in clinical trials than expressions of the statistical significance of differences in outcomes, whether or not a treatment has delivered a specified minimum clinically important difference (MCID) is also relevant to patients and their caregivers and doctors. Many dementia treatment randomised controlled trials (RCTs) have not reported MCIDs and, where they have been done, observed differences have not reached these.",

author = "Robert Howard and Patrick Phillips and Tony Johnson and John O'Brien and Bart Sheehan and James Lindesay and Peter Bentham and Alistair Burns and Clive Ballard and Clive Holmes and Ian McKeith and Robert Barber and Tom Dening and Craig Ritchie and Rob Jones and Ashley Baldwin and Peter Passmore and David Findlay and Alan Hughes and Ajay Macharouthu and Sube Banerjee and Roy Jones and Martin Knapp and Brown, {Richard G} and Robin Jacoby and Jessica Adams and Mary Griffin and Richard Gray",

note = "Copyright {\textcopyright} 2010 John Wiley & Sons, Ltd.",

year = "2011",

month = aug,

doi = "10.1002/gps.2607",

language = "English",

volume = "26",

pages = "812--7",

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Howard, R, Phillips, P, Johnson, T, O'Brien, J, Sheehan, B, Lindesay, J, Bentham, P, Burns, A, Ballard, C, Holmes, C, McKeith, I, Barber, R, Dening, T, Ritchie, C, Jones, R, Baldwin, A, Passmore, P, Findlay, D, Hughes, A, Macharouthu, A, Banerjee, S, Jones, R, Knapp, M, Brown, RG, Jacoby, R, Adams, J, Griffin, M & Gray, R 2011, 'Determining the minimum clinically important differences for outcomes in the DOMINO trial', International Journal of Geriatric Psychiatry, vol. 26, no. 8, pp. 812-7. https://doi.org/10.1002/gps.2607

TY - JOUR

T1 - Determining the minimum clinically important differences for outcomes in the DOMINO trial

AU - Howard, Robert

AU - Phillips, Patrick

AU - Johnson, Tony

AU - O'Brien, John

AU - Sheehan, Bart

AU - Lindesay, James

AU - Bentham, Peter

AU - Burns, Alistair

AU - Ballard, Clive

AU - Holmes, Clive

AU - McKeith, Ian

AU - Barber, Robert

AU - Dening, Tom

AU - Ritchie, Craig

AU - Jones, Rob

AU - Baldwin, Ashley

AU - Passmore, Peter

AU - Findlay, David

AU - Hughes, Alan

AU - Macharouthu, Ajay

AU - Banerjee, Sube

AU - Jones, Roy

AU - Knapp, Martin

AU - Brown, Richard G

AU - Jacoby, Robin

AU - Adams, Jessica

AU - Griffin, Mary

AU - Gray, Richard

PY - 2011/8

Y1 - 2011/8

N2 - Although less likely to be reported in clinical trials than expressions of the statistical significance of differences in outcomes, whether or not a treatment has delivered a specified minimum clinically important difference (MCID) is also relevant to patients and their caregivers and doctors. Many dementia treatment randomised controlled trials (RCTs) have not reported MCIDs and, where they have been done, observed differences have not reached these.

AB - Although less likely to be reported in clinical trials than expressions of the statistical significance of differences in outcomes, whether or not a treatment has delivered a specified minimum clinically important difference (MCID) is also relevant to patients and their caregivers and doctors. Many dementia treatment randomised controlled trials (RCTs) have not reported MCIDs and, where they have been done, observed differences have not reached these.

U2 - 10.1002/gps.2607

DO - 10.1002/gps.2607

M3 - Article

C2 - 20848576

VL - 26

SP - 812

EP - 817

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

IS - 8

ER -

Determining the minimum clinically important differences for outcomes in the DOMINO trial

Abstract

ASJC Scopus subject areas

UN SDGs

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