Developing a series of inhaled reversible peptide inhibitors against Cathepsin S

Hadil Suleiman; Cliff Taggart; Christopher Scott; Richard Williams

Developing a series of inhaled reversible peptide inhibitors against Cathepsin S

Hadil Suleiman, Cliff Taggart, Christopher Scott, Richard Williams

School of Medicine, Dentistry and Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Cystic fibrosis (CF) is an autosomal recessive disease affecting over 100,000 patients globally. Caused by a large number of mutations affecting the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator).
This defect leads to abnormal ion transport across lung cells surface, decreased water level resulting in mucus obstruction, inflammation, and bacterial infection. Figure(1).
Several studies have shown that Cathepsin S (CatS) a cysteine protease found mainly in antigen - presenting cells, to be involved in CF. A study at Queen’s University Belfast, showed it to be elevated in 100% of CF patients. Furthermore, studies using CatS knockout showed improved bacterial clearance and reduced inflammation.

Original language	English
Title of host publication	Winter School (Medicine, Dentistry and Biomedical Sciences) Meeting 2021: Proteinases and their Inhibitors
Publication status	Published - 25 Feb 2021

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@inproceedings{e05f4e71279a4b71aced7092c817ac65,

title = "Developing a series of inhaled reversible peptide inhibitors against Cathepsin S",

abstract = "Cystic fibrosis (CF) is an autosomal recessive disease affecting over 100,000 patients globally. Caused by a large number of mutations affecting the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator).This defect leads to abnormal ion transport across lung cells surface, decreased water level resulting in mucus obstruction, inflammation, and bacterial infection. Figure(1). Several studies have shown that Cathepsin S (CatS) a cysteine protease found mainly in antigen - presenting cells, to be involved in CF. A study at Queen{\textquoteright}s University Belfast, showed it to be elevated in 100% of CF patients. Furthermore, studies using CatS knockout showed improved bacterial clearance and reduced inflammation.",

author = "Hadil Suleiman and Cliff Taggart and Christopher Scott and Richard Williams",

year = "2021",

month = feb,

day = "25",

language = "English",

booktitle = "Winter School (Medicine, Dentistry and Biomedical Sciences) Meeting 2021: Proteinases and their Inhibitors",

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T1 - Developing a series of inhaled reversible peptide inhibitors against Cathepsin S

AU - Suleiman, Hadil

AU - Taggart, Cliff

AU - Scott, Christopher

AU - Williams, Richard

PY - 2021/2/25

Y1 - 2021/2/25

N2 - Cystic fibrosis (CF) is an autosomal recessive disease affecting over 100,000 patients globally. Caused by a large number of mutations affecting the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator).This defect leads to abnormal ion transport across lung cells surface, decreased water level resulting in mucus obstruction, inflammation, and bacterial infection. Figure(1). Several studies have shown that Cathepsin S (CatS) a cysteine protease found mainly in antigen - presenting cells, to be involved in CF. A study at Queen’s University Belfast, showed it to be elevated in 100% of CF patients. Furthermore, studies using CatS knockout showed improved bacterial clearance and reduced inflammation.

AB - Cystic fibrosis (CF) is an autosomal recessive disease affecting over 100,000 patients globally. Caused by a large number of mutations affecting the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator).This defect leads to abnormal ion transport across lung cells surface, decreased water level resulting in mucus obstruction, inflammation, and bacterial infection. Figure(1). Several studies have shown that Cathepsin S (CatS) a cysteine protease found mainly in antigen - presenting cells, to be involved in CF. A study at Queen’s University Belfast, showed it to be elevated in 100% of CF patients. Furthermore, studies using CatS knockout showed improved bacterial clearance and reduced inflammation.

M3 - Conference contribution

BT - Winter School (Medicine, Dentistry and Biomedical Sciences) Meeting 2021: Proteinases and their Inhibitors

ER -