Developing an international Pseudomonas aeruginosa reference panel

Anthony De Soyza, Amanda J Hall, Eshwar Mahenthiralingam, Pavel Drevinek, Wieslaw Kaca, Zuzanna Drulis-Kawa, Stoyanka R Stoitsova, Veronika Toth, Tom Coenye, James E A Zlosnik, Jane L Burns, Isabel Sá-Correia, Daniel De Vos, Jean-Paul Pirnay, Timothy J Kidd, David Reid, Jim Manos, Jens Klockgether, Lutz Wiehlmann, Burkhard TümmlerSiobhán McClean, Craig Winstanley, EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens”

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.

Original languageEnglish
Pages (from-to)1010-23
Number of pages14
JournalMicrobiologyOpen
Volume2
Issue number6
DOIs
Publication statusPublished - Dec 2013

Bibliographical note

© 2013 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

Keywords

  • Biomedical Research
  • Cystic Fibrosis
  • Humans
  • International Cooperation
  • Microbiology
  • Pneumonia, Bacterial
  • Pseudomonas Infections
  • Pseudomonas aeruginosa
  • Reference Standards

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