Developing an international Pseudomonas aeruginosa reference panel

Anthony De Soyza; Amanda J Hall; Eshwar Mahenthiralingam; Pavel Drevinek; Wieslaw Kaca; Zuzanna Drulis-Kawa; Stoyanka R Stoitsova; Veronika Toth; Tom Coenye; James E A Zlosnik; Jane L Burns; Isabel Sá-Correia; Daniel De Vos; Jean-Paul Pirnay; Timothy J Kidd; David Reid; Jim Manos; Jens Klockgether; Lutz Wiehlmann; Burkhard Tümmler; Siobhán McClean; Craig Winstanley; EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens”

doi:10.1002/mbo3.141

Developing an international Pseudomonas aeruginosa reference panel

Anthony De Soyza, Amanda J Hall, Eshwar Mahenthiralingam, Pavel Drevinek, Wieslaw Kaca, Zuzanna Drulis-Kawa, Stoyanka R Stoitsova, Veronika Toth, Tom Coenye, James E A Zlosnik, Jane L Burns, Isabel Sá-Correia, Daniel De Vos, Jean-Paul Pirnay, Timothy J Kidd, David Reid, Jim Manos, Jens Klockgether, Lutz Wiehlmann, Burkhard TümmlerSiobhán McClean, Craig Winstanley, EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens”

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.

Original language	English
Pages (from-to)	1010-23
Number of pages	14
Journal	MicrobiologyOpen
Volume	2
Issue number	6
DOIs	https://doi.org/10.1002/mbo3.141
Publication status	Published - Dec 2013

Bibliographical note

Keywords

Biomedical Research
Cystic Fibrosis
Humans
International Cooperation
Microbiology
Pneumonia, Bacterial
Pseudomonas Infections
Pseudomonas aeruginosa
Reference Standards

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10.1002/mbo3.141

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De Soyza, A., Hall, A. J., Mahenthiralingam, E., Drevinek, P., Kaca, W., Drulis-Kawa, Z., Stoitsova, S. R., Toth, V., Coenye, T., Zlosnik, J. E. A., Burns, J. L., Sá-Correia, I., De Vos, D., Pirnay, J.-P., Kidd, T. J., Reid, D., Manos, J., Klockgether, J., Wiehlmann, L., ... EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens” (2013). Developing an international Pseudomonas aeruginosa reference panel. MicrobiologyOpen, 2(6), 1010-23. https://doi.org/10.1002/mbo3.141

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title = "Developing an international Pseudomonas aeruginosa reference panel",

abstract = "Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.",

keywords = "Biomedical Research, Cystic Fibrosis, Humans, International Cooperation, Microbiology, Pneumonia, Bacterial, Pseudomonas Infections, Pseudomonas aeruginosa, Reference Standards",

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year = "2013",

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doi = "10.1002/mbo3.141",

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De Soyza, A, Hall, AJ, Mahenthiralingam, E, Drevinek, P, Kaca, W, Drulis-Kawa, Z, Stoitsova, SR, Toth, V, Coenye, T, Zlosnik, JEA, Burns, JL, Sá-Correia, I, De Vos, D, Pirnay, J-P, Kidd, TJ, Reid, D, Manos, J, Klockgether, J, Wiehlmann, L, Tümmler, B, McClean, S, Winstanley, C & EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens” 2013, 'Developing an international Pseudomonas aeruginosa reference panel', MicrobiologyOpen, vol. 2, no. 6, pp. 1010-23. https://doi.org/10.1002/mbo3.141

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T1 - Developing an international Pseudomonas aeruginosa reference panel

AU - De Soyza, Anthony

AU - Hall, Amanda J

AU - Mahenthiralingam, Eshwar

AU - Drevinek, Pavel

AU - Kaca, Wieslaw

AU - Drulis-Kawa, Zuzanna

AU - Stoitsova, Stoyanka R

AU - Toth, Veronika

AU - Coenye, Tom

AU - Zlosnik, James E A

AU - Burns, Jane L

AU - Sá-Correia, Isabel

AU - De Vos, Daniel

AU - Pirnay, Jean-Paul

AU - Kidd, Timothy J

AU - Reid, David

AU - Manos, Jim

AU - Klockgether, Jens

AU - Wiehlmann, Lutz

AU - Tümmler, Burkhard

AU - McClean, Siobhán

AU - Winstanley, Craig

AU - EU FP7 funded COST Action BM1003 “Cell surface virulence determinants of cystic fibrosis pathogens”

PY - 2013/12

Y1 - 2013/12

N2 - Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.

AB - Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.

KW - Biomedical Research

KW - Cystic Fibrosis

KW - Humans

KW - International Cooperation

KW - Microbiology

KW - Pneumonia, Bacterial

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Reference Standards

U2 - 10.1002/mbo3.141

DO - 10.1002/mbo3.141

M3 - Article

C2 - 24214409

VL - 2

SP - 1010

EP - 1023

JO - MicrobiologyOpen

JF - MicrobiologyOpen

IS - 6

ER -

Developing an international Pseudomonas aeruginosa reference panel

Abstract

Bibliographical note

Keywords

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