Development and validation of a lateral flow device for the detection of nicarbazin contamination in poultry feeds

Katrina Campbell, T. Fodey, J. Flint, C. Danks, M. Danaher, M. O'Keeffe, David Kennedy, Christopher Elliott

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Concentrations of the coccidiostat nicarbazin as low as 2 mg/kg in feed can result in violative drug residues arising in poultry liver. A lateral flow device (LFD) was developed for the detection of contaminating concentrations of nicarbazin following solvent extraction of poultry feeds. Test results, as determined by both visual and instrumental measurement, are available within minutes. For 22 feed samples, nicarbazin-free and fortified at 2 mg/kg, the % relative inhibition ranged from 0 to 45% and from 53 to 85%, respectively. Nicarbazin contamination at the critical concentration (2 mg/kg) can be determined in all cases providing the sampling is representative. A wide range of feed samples taken at a mill that incorporated nicarbazin into poultry feed were analyzed. Data generated for these samples by both the LFDs and a mass spectrometric method were compared, and a significant correlation was achieved.
Original languageEnglish
Pages (from-to)2497-2503
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume55 (6)
Issue number6
DOIs
Publication statusPublished - 21 Mar 2007

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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