Abstract
Implantable drug delivery devices offer many advantages over other routes of drug delivery. Most significantly, the delivery of lower doses of drug, thus, potentially reducing side-effects and improving patient compliance. Three dimensional (3D) printing is a flexible technique, which has been subject to increasing interest in the past few years, especially in the area of medical devices. The present work focussed on the use of 3D printing as a tool to manufacture implantable drug delivery devices to deliver a range of model compounds (methylene blue, ibuprofen sodium and ibuprofen acid) in two in vitro models. Five implant designs were produced, and the release rate varied, depending on the implant design and the drug properties. Additionally, a rate controlling membrane was produced, which further prolonged the release from the produced implants, signalling the potential use of these devices for chronic conditions.
Original language | English |
---|---|
Article number | 105 |
Number of pages | 16 |
Journal | Pharmaceutics |
Volume | 12 |
Issue number | 2 |
DOIs | |
Publication status | Published - 28 Jan 2020 |
Fingerprint Dive into the research topics of 'Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing'. Together they form a unique fingerprint.
Student Theses
-
Development of biodegradable implants for sustained drug delivery
Author: Stewart, S., Jul 2021Supervisor: Larraneta Landa, E. (Supervisor), Donnelly, R. (Supervisor) & Dominguez Robles, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy