Development of a bovine collagen-apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty

Rochelle M. O'Hara, John F. Orr, Fraser J. Buchanan, Ruth K. Wilcox, David C. Barton, Nicholas J. Dunne

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32 Citations (Scopus)


The aim of this study was to examine the potential of incorporating bovine fibres as a means of reinforcing a typically brittle apatite calcium phosphate cement for vertebroplasty. Type I collagen derived from bovine Achilles tendon was ground cryogenically to produce an average fibre length of 0.96 ± 0.55 mm and manually mixed into the powder phase of an apatite-based cement at 1, 3 or 5 wt.%. Fibre addition of up to 5 wt.% had a significant effect (P = 0.001) on the fracture toughness, which was increased by 172%. Adding =1 wt.% bovine collagen fibres did not compromise the compressive properties significantly, however, a decrease of 39-53% was demonstrated at =3 wt.% fibre loading. Adding bovine collagen to the calcium phosphate cement reduced the initial and final setting times to satisfy the clinical requirements stated for vertebroplasty. The cement viscosity increased in a linear manner (R = 0.975) with increased loading of collagen fibres, such that the injectability was found to be reduced by 83% at 5 wt.% collagen loading. This study suggests for the first time the potential application of a collagen-reinforced calcium phosphate cement as a viable option in the treatment of vertebral fractures, however, issues surrounding efficacious cement delivery need to be addressed.
Original languageEnglish
Pages (from-to)4043-4052
Number of pages10
JournalActa Biomaterialia
Issue number11
Publication statusPublished - Nov 2012

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Copyright 2012 Elsevier B.V., All rights reserved.

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