Development of Disulfiram-Loaded Vaginal Rings for the Localised Treatment of Cervical Cancer

Peter Boyd, Ian Major, Weiguang Wang, Christopher McConville

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cervical cancer is the third most prevalent cancer in women and disproportionately affects those in low resource settings due to limited programs for screening and prevention. In the developed world treatment for the disease in the non-metastasised state usually takes the form of surgical intervention and/or radiotherapy. In the developing world such techniques are less widely available. This paper describes the development of an intravaginal ring for the localised delivery of a chemotherapeutic drug to the cervix that has the potential to reduce the need for surgical intervention and will also provide a novel anti-cancer therapy for women in low resource settings. Disulfiram has demonstrated antineoplastic action against prostate, breast and lung cancer. Both PEVA and silicone elastomer were investigated for suitability as materials in the manufacture of DSF eluting intravaginal rings. DSF inhibited the curing process of the silicone elastomer, therefore PEVA was chosen as the material to manufacture the DSF-loaded vaginal rings. The vaginal rings had an excellent content uniformity while the DSF remained stable throughout the manufacturing process. Furthermore, the rings provided diffusion controlled release of DSF at levels well in excess of the IC50 value for the HeLa cervical cancer cell line.
Original languageEnglish
Pages (from-to)945-953
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume88
Issue number3
Early online date13 Aug 2014
DOIs
Publication statusPublished - Nov 2014

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