Development of Geraniol-Loaded Liposomal Nanoformulations against Salmonella Colonization in the Pig Gut

Sotiriοs Ι. Εkonomou, Pooja-Akshay Thanekar, Dimitrios Lamprou, Edward Weaver, Olena Doran, Alexandros Stratakos

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
104 Downloads (Pure)

Abstract

Salmonella is a global health threat with pig production being one of the main sources of human salmonellosis. The current study investigated the antivirulence properties of geraniol for inhibiting the in vitro colonization of Salmonella. The minimum inhibitory (MIC) and bactericidal concentrations (MBC) of geraniol against Salmonella Typhimurium followed by the sub-MIC of geraniol were determined. Results provided clear evidence that geraniol at 1/8-MIC can be used as an effective, non-toxic antivirulence compound to inhibit virulence factors (motility, adhesion, invasiveness) affecting the colonization of S. Typhimurium on IPEC-J2 cells. Additionally, the findings signified that microfluidics is an emerging technology suitable for the preparation of stable liposomes with small size (<200 nm) and high encapsulation efficiency (EE) up to 92.53%, that can act as effective carriers of geraniol into the pig gastrointestinal tract (GIT); targeting Salmonella and preventing colonization and thus increasing the safety of the food supply chain.
Original languageEnglish
JournalJournal of Agricultural and Food Chemistry
Early online date02 Jun 2022
DOIs
Publication statusEarly online date - 02 Jun 2022

Keywords

  • Salmonella
  • Liposomes
  • Microfluidics
  • Gastrointestinal Tract
  • Geraniol
  • Pig

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