Development of multi-dose oral sustained release suspensions for older patients with dysphagia

Kavil Patel, Valentyn Mohylyuk, Darragh Murnane, Craig Richardson, Fang Liu*

*Corresponding author for this work

Research output: Contribution to conferencePosterpeer-review

Abstract

The present study was aimed at the development of a redispersible multi-dose suspension based on coated microparticles to ensure easy swallowing and sustained release of metoprolol succinate. To provide sustained release of metoprolol succinate, the microparticles were prepared by drug loading and Eudragit NM coating in a fluid-bed coater. Compositions of the liquid suspension vehicle were selected to reduce solubility of metoprolol succinate. The effect of vehicle composition and suspension storage time at RT on drug leaching into the suspension vehicle and on the drug release profile were investigated. The approach allowed a redispersible multi-dose suspension of metoprolol microparticles which, after one month storage, displayed negligible drug leaching into the suspension vehicle and a sustained release profile comparable to the profile before storage.
Original languageEnglish
Pages1
Number of pages1
Publication statusPublished - 07 Sep 2018
Externally publishedYes

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