Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.

Christopher McConville; Ian Major; David R. Friend; Meredith R. Clark; A. David Woolfson; R. Karl Malcolm

doi:10.1002/jbm.b.31919

Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.

Christopher McConville, Ian Major, David R. Friend, Meredith R. Clark, A. David Woolfson, R. Karl Malcolm

Queen's University Belfast

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Vaginal rings are currently being investigated fordelivery of HIV microbicides. However, vaginal rings are cur-rently manufactured form hydrophobic polymers such as sili-cone elastomer and polyethylene vinyl acetate (PEVA), whichdo not permit release of hydrophilic microbicides such as thenucleotide reverse transcriptase inhibitor tenofovir. Biodegrad-able polymers such as polylactide (PLA) may help increaserelease rates by controlling polymer degradation rather thandiffusion of the drug through the polymer. However, biodegrad-able polymers have limited flexibility making them unsuitablefor use in the manufacture of vaginal rings. This study demon-strates that by blending PLA and PEVA together it is possible toachieve a blend that has flexibility similar to native PEVA butalso allows for the release of tenofovir.

Original language	English
Pages (from-to)	891-895
Number of pages	5
Journal	Journal of biomedical materials research. Part B, Applied biomaterials
Volume	100B
Issue number	4
Early online date	21 Mar 2012
DOIs	https://doi.org/10.1002/jbm.b.31919
Publication status	Published - 2012

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abstract = "Vaginal rings are currently being investigated fordelivery of HIV microbicides. However, vaginal rings are cur-rently manufactured form hydrophobic polymers such as sili-cone elastomer and polyethylene vinyl acetate (PEVA), whichdo not permit release of hydrophilic microbicides such as thenucleotide reverse transcriptase inhibitor tenofovir. Biodegrad-able polymers such as polylactide (PLA) may help increaserelease rates by controlling polymer degradation rather thandiffusion of the drug through the polymer. However, biodegrad-able polymers have limited flexibility making them unsuitablefor use in the manufacture of vaginal rings. This study demon-strates that by blending PLA and PEVA together it is possible toachieve a blend that has flexibility similar to native PEVA butalso allows for the release of tenofovir.",

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AU - Major, Ian

AU - Friend, David R.

AU - Clark, Meredith R.

AU - Woolfson, A. David

AU - Malcolm, R. Karl

PY - 2012

Y1 - 2012

N2 - Vaginal rings are currently being investigated fordelivery of HIV microbicides. However, vaginal rings are cur-rently manufactured form hydrophobic polymers such as sili-cone elastomer and polyethylene vinyl acetate (PEVA), whichdo not permit release of hydrophilic microbicides such as thenucleotide reverse transcriptase inhibitor tenofovir. Biodegrad-able polymers such as polylactide (PLA) may help increaserelease rates by controlling polymer degradation rather thandiffusion of the drug through the polymer. However, biodegrad-able polymers have limited flexibility making them unsuitablefor use in the manufacture of vaginal rings. This study demon-strates that by blending PLA and PEVA together it is possible toachieve a blend that has flexibility similar to native PEVA butalso allows for the release of tenofovir.

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Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.

Abstract

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