Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.

Christopher McConville, Ian Major, David R. Friend, Meredith R. Clark, A. David Woolfson, R. Karl Malcolm

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Vaginal rings are currently being investigated fordelivery of HIV microbicides. However, vaginal rings are cur-rently manufactured form hydrophobic polymers such as sili-cone elastomer and polyethylene vinyl acetate (PEVA), whichdo not permit release of hydrophilic microbicides such as thenucleotide reverse transcriptase inhibitor tenofovir. Biodegrad-able polymers such as polylactide (PLA) may help increaserelease rates by controlling polymer degradation rather thandiffusion of the drug through the polymer. However, biodegrad-able polymers have limited flexibility making them unsuitablefor use in the manufacture of vaginal rings. This study demon-strates that by blending PLA and PEVA together it is possible toachieve a blend that has flexibility similar to native PEVA butalso allows for the release of tenofovir.
Original languageEnglish
Pages (from-to)891-895
Number of pages5
JournalJournal of biomedical materials research. Part B, Applied biomaterials
Volume100B
Issue number4
Early online date21 Mar 2012
DOIs
Publication statusPublished - 2012

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