TY - JOUR
T1 - Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol
AU - Aloisio, Carolina
AU - Bueno, María Soledad
AU - Ponte, Micaela Ponce
AU - Paredes, Alejandro
AU - Palma, Santiago Daniel
AU - Longhi, Marcela
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES).
Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C).
Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5.
Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles.
Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.
AB - Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES).
Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C).
Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5.
Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles.
Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.
U2 - 10.4155/tde-2019-0054
DO - 10.4155/tde-2019-0054
M3 - Article
VL - 10
SP - 626
EP - 641
JO - Therapeutic Delivery
JF - Therapeutic Delivery
SN - 2041-5990
IS - 10
ER -