Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol

Carolina Aloisio; María Soledad Bueno; Micaela Ponce Ponte; Alejandro Paredes; Santiago Daniel Palma; Marcela Longhi

doi:10.4155/tde-2019-0054

Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol

Carolina Aloisio, María Soledad Bueno, Micaela Ponce Ponte, Alejandro Paredes, Santiago Daniel Palma, Marcela Longhi

School of Pharmacy

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.

Original language	English
Pages (from-to)	626-641
Journal	Therapeutic Delivery
Volume	10
Issue number	10
DOIs	https://doi.org/10.4155/tde-2019-0054
Publication status	Published - 01 Nov 2019

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Aloisio, C., Bueno, M. S., Ponte, M. P., Paredes, A., Palma, S. D., & Longhi, M. (2019). Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol. Therapeutic Delivery, 10(10), 626-641. https://doi.org/10.4155/tde-2019-0054

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title = "Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol",

abstract = "Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin{\textregistered} HRE-40 (EU)/Sodium oleate (system A); SPC/Tween{\textregistered}80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.",

author = "Carolina Aloisio and Bueno, {Mar{\'i}a Soledad} and Ponte, {Micaela Ponce} and Alejandro Paredes and Palma, {Santiago Daniel} and Marcela Longhi",

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T1 - Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol

AU - Aloisio, Carolina

AU - Bueno, María Soledad

AU - Ponte, Micaela Ponce

AU - Paredes, Alejandro

AU - Palma, Santiago Daniel

AU - Longhi, Marcela

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.

AB - Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.

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SN - 2041-5990

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