Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol

Carolina Aloisio, María Soledad Bueno, Micaela Ponce Ponte, Alejandro Paredes, Santiago Daniel Palma, Marcela Longhi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.
Original languageEnglish
Pages (from-to)626-641
JournalTherapeutic Delivery
Volume10
Issue number10
DOIs
Publication statusPublished - 01 Nov 2019

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