Development of the nervous system in Dugesia tigrina during regeneration after fission and decapitation

M. Reuter, I.M. Sheiman, M.K.S. Gustafsson, D W Halton, Aaron Maule, Christopher Shaw

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

In the present study of Dugesia tigrina the development of the nervous system is followed and compared during regeneration after fission and after decapitation. Immunocytochemistry was used, with antisera raised against the biogenic amine, 5-hydroxytryptamine (5-HT) and the two neuropeptides, neuropeptide F (NPF), and FMRF amide. The results indicate that two processes are involved in the formation of the new cerebral ganglion. First, new processes sprouting from the original main longitudinal nerve cords bend transversely, indicating the position of the developing horseshoe-shaped anterior cerebral commissure. Then new nerve cells in front of the commissure differentiate from neoblasts and their growth cones fasciculate with the fibres from the old main longitudinal nerve cords. In the cerebral ganglion, 5-HT-IR cells appear before NPF-IR cells, in contrast to the pharynx where NPF-IR cells differentiate before the 5-HT-IR cells. In the peripheral nervous system, NPF-IR fibres and cells appear at a very early stage and dominate the whole regeneration process. A role for the PNS in early pattern formation is suggested.
Original languageEnglish
Pages (from-to)199-211
Number of pages13
JournalINVERTEBRATE REPRODUCTION & DEVELOPMENT
Volume29
Publication statusPublished - 1996

Fingerprint Dive into the research topics of 'Development of the nervous system in Dugesia tigrina during regeneration after fission and decapitation'. Together they form a unique fingerprint.

Cite this