Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease

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Abstract

Purpose of Review
Nutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer’s disease (AD) and progression of neurodegeneration. Here, we review the evidence for healthy dietary patterns and age-related cognition and discuss potential neuroinflammatory actions of diet on cognitive function.

Recent Findings
Anti-inflammatory dietary patterns such as the Mediterranean diet (MD) and dietary approaches to stop hypertension (DASH) may be neuroprotective. Several dietary components consumed in the MD and DASH (omega-3 fatty acids, antioxidants and polyphenols) can inhibit neuroinflammation associated with AD. Anti-inflammatory diets may also attenuate neuroinflammation via indirect immune pathways from the gut microbiome and systemic circulation.

Summary
Diet may influence cognitive ageing via several inflammatory pathways. However, data from human studies are lacking and the exact mechanisms linking diet to cognitive function remain elusive. Further dietary intervention studies are required to investigate diet-associated neurological change from the earliest through to latest stages of cognitive decline. Furthermore, incorporation of neuroimaging measures in intervention studies would advance current understanding of the mechanistic effects of dietary modification on neuroinflammation in the ageing brain.
Original languageEnglish
JournalCurrent Nutrition Reports
Early online date04 Apr 2019
DOIs
Publication statusEarly online date - 04 Apr 2019

Fingerprint

Alzheimer disease
Alzheimer Disease
inflammation
cognition
Cognition
Diet
Inflammation
Mediterranean Diet
Mediterranean diet
eating habits
diet
hypertension
Hypertension
Diet Therapy
Omega-3 Fatty Acids
Polyphenols
action potentials
Neuroimaging
omega-3 fatty acids
Action Potentials

Keywords

  • Diet
  • Inflammation
  • Cognitive aging

Cite this

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title = "Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease",
abstract = "Purpose of ReviewNutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer’s disease (AD) and progression of neurodegeneration. Here, we review the evidence for healthy dietary patterns and age-related cognition and discuss potential neuroinflammatory actions of diet on cognitive function.Recent FindingsAnti-inflammatory dietary patterns such as the Mediterranean diet (MD) and dietary approaches to stop hypertension (DASH) may be neuroprotective. Several dietary components consumed in the MD and DASH (omega-3 fatty acids, antioxidants and polyphenols) can inhibit neuroinflammation associated with AD. Anti-inflammatory diets may also attenuate neuroinflammation via indirect immune pathways from the gut microbiome and systemic circulation.SummaryDiet may influence cognitive ageing via several inflammatory pathways. However, data from human studies are lacking and the exact mechanisms linking diet to cognitive function remain elusive. Further dietary intervention studies are required to investigate diet-associated neurological change from the earliest through to latest stages of cognitive decline. Furthermore, incorporation of neuroimaging measures in intervention studies would advance current understanding of the mechanistic effects of dietary modification on neuroinflammation in the ageing brain.",
keywords = "Diet, Inflammation, Cognitive aging",
author = "McGrattan, {Andrea M.} and Bernadette McGuinness and McKinley, {Michelle C.} and Frank Kee and Peter Passmore and Woodside, {Jayne V.} and McEvoy, {Claire T.}",
year = "2019",
month = "4",
day = "4",
doi = "10.1007/s13668-019-0271-4",
language = "English",
journal = "Current Nutrition Reports",
issn = "2161-3311",
publisher = "Springer",

}

TY - JOUR

T1 - Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease

AU - McGrattan, Andrea M.

AU - McGuinness, Bernadette

AU - McKinley, Michelle C.

AU - Kee, Frank

AU - Passmore, Peter

AU - Woodside, Jayne V.

AU - McEvoy, Claire T.

PY - 2019/4/4

Y1 - 2019/4/4

N2 - Purpose of ReviewNutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer’s disease (AD) and progression of neurodegeneration. Here, we review the evidence for healthy dietary patterns and age-related cognition and discuss potential neuroinflammatory actions of diet on cognitive function.Recent FindingsAnti-inflammatory dietary patterns such as the Mediterranean diet (MD) and dietary approaches to stop hypertension (DASH) may be neuroprotective. Several dietary components consumed in the MD and DASH (omega-3 fatty acids, antioxidants and polyphenols) can inhibit neuroinflammation associated with AD. Anti-inflammatory diets may also attenuate neuroinflammation via indirect immune pathways from the gut microbiome and systemic circulation.SummaryDiet may influence cognitive ageing via several inflammatory pathways. However, data from human studies are lacking and the exact mechanisms linking diet to cognitive function remain elusive. Further dietary intervention studies are required to investigate diet-associated neurological change from the earliest through to latest stages of cognitive decline. Furthermore, incorporation of neuroimaging measures in intervention studies would advance current understanding of the mechanistic effects of dietary modification on neuroinflammation in the ageing brain.

AB - Purpose of ReviewNutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer’s disease (AD) and progression of neurodegeneration. Here, we review the evidence for healthy dietary patterns and age-related cognition and discuss potential neuroinflammatory actions of diet on cognitive function.Recent FindingsAnti-inflammatory dietary patterns such as the Mediterranean diet (MD) and dietary approaches to stop hypertension (DASH) may be neuroprotective. Several dietary components consumed in the MD and DASH (omega-3 fatty acids, antioxidants and polyphenols) can inhibit neuroinflammation associated with AD. Anti-inflammatory diets may also attenuate neuroinflammation via indirect immune pathways from the gut microbiome and systemic circulation.SummaryDiet may influence cognitive ageing via several inflammatory pathways. However, data from human studies are lacking and the exact mechanisms linking diet to cognitive function remain elusive. Further dietary intervention studies are required to investigate diet-associated neurological change from the earliest through to latest stages of cognitive decline. Furthermore, incorporation of neuroimaging measures in intervention studies would advance current understanding of the mechanistic effects of dietary modification on neuroinflammation in the ageing brain.

KW - Diet

KW - Inflammation

KW - Cognitive aging

U2 - 10.1007/s13668-019-0271-4

DO - 10.1007/s13668-019-0271-4

M3 - Review article

JO - Current Nutrition Reports

JF - Current Nutrition Reports

SN - 2161-3311

ER -