Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure

Candida P Shirima, Martin E Kimanya, Joyce L Kinabo, Michael N Routledge, Chou Srey, Christopher P Wild, Yun Yun Gong

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Abstract

SCOPEThe study aims to evaluate the status of dietary exposure to aflatoxin and fumonisin in young Tanzanian children, using previously validated biomarkers of exposure.
METHODS AND RESULTSA total of 148 children aged 12-22 months, were recruited from three geographically distant villages in Tanzania; Nyabula, Kigwa, and Kikelelwa. Plasma aflatoxin-albumin adducts (AF-alb) and urinary fumonisin B1 (UFB1) were measured by ELISA and LC-MS, respectively. AF-alb was detectable in 84% of children, was highest in fully weaned children (p <0.01) with higher levels being associated with higher maize intake (p <0.05). AF-alb geometric mean (95% CI) was 43.2 (28.7-65.0), 19.9 (13.5-29.2), and 3.6 (2.8-4.7) pg/mg albumin in children from Kigwa, Nyabula, and Kikelelwa, respectively. UFB1 was detectable in 96% of children and the level was highest in children who had been fully weaned (p <0.01). The geometric UFB1 mean (95% CI) was 327.2 (217.1-493.0), 211.7 (161.1-278.1), and 82.8 (58.3-117.7) pg/mL in Kigwa, Nyabula, and Kikelelwa, respectively. About 82% of all the children were exposed to both mycotoxins. 
CONCLUSION Young children in Tanzania are chronically exposed to both aflatoxin and fumonisin through contaminated diet, although the level of exposure varies markedly between the three villages studied.
Original languageEnglish
Pages (from-to)1874-1881
JournalMolecular Nutrition & Food Research
Volume57
Issue number10
Early online date17 Jun 2013
DOIs
Publication statusPublished - Oct 2013

Bibliographical note

© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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    Shirima, C. P., Kimanya, M. E., Kinabo, J. L., Routledge, M. N., Srey, C., Wild, C. P., & Gong, Y. Y. (2013). Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure. Molecular Nutrition & Food Research, 57(10), 1874-1881. https://doi.org/10.1002/mnfr.201300116