Dietary fat and breast cancer mortality: a systematic review and meta-analysis

Sarah F Brennan, Jayne V Woodside, Paula M Lunny, Chris R Cardwell, Marie M Cantwell

Research output: Contribution to journalArticle

22 Citations (Scopus)
561 Downloads (Pure)

Abstract

Background: The influence of dietary fat upon breast cancer mortality remains largely understudied despite extensive investigation into its influence upon breast cancer risk 

Objective: To conduct meta-analyses of studies to clarify the association between dietary fat and breast cancer mortality Design: MEDLINE and EMBASE were searched for relevant articles published up to March 2012. Risk of all-cause or breast cancer specific death was evaluated by combining multivariable adjusted estimates comparing highest versus lowest categories of intake; and per 20 gram increase in intake of total and/or saturated fat (g/day) using random-effects meta-analyses. 

Results: Fifteen prospective cohort studies investigating total fat and/or saturated fat intake (g/day) and breast cancer mortality were included. There was no difference in risk of breast cancer specific death (n = 6; HR = 1.14; 95% CI: 0.86, 1.52; P = 0.34) or all cause death (n = 4; HR = 1.73; 95% CI: 0.82, 3.6; P = 0.15) for women in the highest versus lowest category of total fat intake. Breast cancer specific death (n = 5; HR = 1.63; 95% CI: 1.19, 2.24; p <0.01) was higher for women in the highest versus lowest category of saturated fat intake. 

Conclusions: These meta-analyses have shown that saturated fat intake negatively impacts upon breast cancer survival.

Original languageEnglish
JournalCritical Reviews in Food Science and Nutrition
Early online date18 Feb 2015
DOIs
Publication statusEarly online date - 18 Feb 2015

Fingerprint Dive into the research topics of 'Dietary fat and breast cancer mortality: a systematic review and meta-analysis'. Together they form a unique fingerprint.

  • Cite this