Dietary fiber and the risk of precancerous lesions and cancer of the esophagus a systematic review and meta-analysis

Helen G Coleman, Liam J Murray, Blanaid Hicks, Shivaram K Bhat, Ai Kubo, Douglas A Corley, Chris R Cardwell, Marie M Cantwell

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Dietary fiber has several anticarcinogenic effects and is thought to be protective against esophageal cancer. The aim of this systematic review was to quantify the association between dietary fiber and the risk of esophageal cancer by investigating histological subtypes of esophageal cancer and the stage at which fiber may influence the carcinogenic pathway. Systematic search strategies were used to identify relevant studies, and adjusted odds ratios (ORs) were combined using random-effects meta-analyses to assess the risk of cancer when comparing extreme categories of fiber intake. Ten relevant case-control studies were identified within the timeframe searched. Pooled estimates from eight studies of esophageal adenocarcinoma revealed a significant inverse association with the highest fiber intakes (OR 0.66; 95% confidence interval [CI] 0.44-0.98). Two studies also identified protective effects of dietary fiber against Barrett's esophagus. Similar, though nonsignificant, associations were observed when results from five studies of fiber intake and risk of squamous cell carcinoma were combined (OR 0.61; 95%CI 0.31-1.20). Dietary fiber is associated with protective effects against esophageal carcinogenesis, most notably esophageal adenocarcinoma. Potential methods of action include modification of gastroesophageal reflux and/or weight control.
Original languageEnglish
Pages (from-to)474-82
JournalNutrition Reviews
Volume71
Issue number7
DOIs
Publication statusPublished - Jul 2013

Bibliographical note

© 2013 International Life Sciences Institute.

Keywords

  • Adenocarcinoma
  • Anticarcinogenic Agents
  • Diet
  • Dietary Fiber
  • Esophageal Neoplasms
  • Humans
  • Precancerous Conditions
  • Risk Factors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Dietary fiber and the risk of precancerous lesions and cancer of the esophagus a systematic review and meta-analysis'. Together they form a unique fingerprint.

  • Cite this