Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies

The InterAct Consortium

doi:10.1007/s00125-015-3585-9

Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies

The InterAct Consortium

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Abstract

Aims/hypothesis: Intake of dietary fibre has been associated with a reduced risk of type 2 diabetes, but few European studies have been published on this. We evaluated the association between intake of dietary fibre and type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study and in a meta-analysis of prospective studies.

Methods: During 10.8 years of follow-up, 11,559 participants with type 2 diabetes were identified and a subcohort of 15,258 participants was selected for the case-cohort study. Country-specific HRs were estimated using Prentice-weighted Cox proportional hazards models and were pooled using a random effects meta-analysis. Eighteen other cohort studies were identified for the meta-analysis.

Results: In the EPIC-InterAct Study, dietary fibre intake was associated with a lower risk of diabetes (HR_{Q4 vs Q1} 0.82; 95% CI 0.69, 0.97) after adjustment for lifestyle and dietary factors. Similar inverse associations were observed for the intake of cereal fibre and vegetable fibre, but not fruit fibre. The associations were attenuated and no longer statistically significant after adjustment for BMI. In the meta-analysis (19 cohorts), the summary RRs per 10 g/day increase in intake were 0.91 (95% CI 0.87, 0.96) for total fibre, 0.75 (95% CI 0.65, 0.86) for cereal fibre, 0.95 (95% CI 0.87, 1.03) for fruit fibre and 0.93 (95% CI 0.82, 1.05) for vegetable fibre.

Conclusions/interpretation: The overall evidence indicates that the intake of total and cereal fibre is inversely related to the risk of type 2 diabetes. The results of the EPIC-InterAct Study suggest that the association may be partially explained by body weight.

Original language	English
Pages (from-to)	1394-1408
Number of pages	15
Journal	Diabetologia
Volume	58
Issue number	7
Early online date	29 May 2015
DOIs	https://doi.org/10.1007/s00125-015-3585-9
Publication status	Published - 20 Jul 2015
Externally published	Yes

Bibliographical note

Funding Information:
The InterAct project was supported by the European Union (LSHM-CT-2006-037197) in the Framework Programme 6; DA was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU); TN was supported by the World Cancer Research Fund (WCRF); JWJB and IS were supported by the Netherlands Agency grant IGE05012 and Incentive Grant from the Board of the UMC Utrecht; DLVDA and AMWS were supported by the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) and Statistics Netherlands; DP was supported by Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy; TK and AW were supported by the German Cancer Aid, German Cancer Research Center (DKFZ Heidelberg) and German Federal Ministry of Education and Research; PA was supported by the Regional Basque Country Government; GB was supported by The Spanish Ministry of Health (ISCIII RETICC RD06/0020/0091) and the Catalan Institute of Oncology; AT and CK were supported by the Danish Cancer Society; MLR was supported by the Government of the Principality of Asturias; SP was supported by Compagnia di San Paolo; PWF was supported by the Swedish Research Council, Novo Nordisk, Swedish Diabetes Association and Swedish Heart-Lung Foundation; OR was supported by the Västerboten County Council; TJK was supported by the Cancer Research UK; NJW, SS, CL and NGF are supported by the Medical Research Council Epidemiology Unit MC_UU_12015/1 and MC_UU_12015/5.

Publisher Copyright:
© 2015, The Author(s).

Keywords

Case-cohort
Dietary fibre
EPIC-InterAct
Meta-analysis
Type 2 diabetes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies
Copyright 2015 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 468 KBLicence: CC BY

Cite this

@article{1a0d6ca17c054c27b1db5c07649f5444,

title = "Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies",

abstract = "Aims/hypothesis: Intake of dietary fibre has been associated with a reduced risk of type 2 diabetes, but few European studies have been published on this. We evaluated the association between intake of dietary fibre and type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study and in a meta-analysis of prospective studies. Methods: During 10.8 years of follow-up, 11,559 participants with type 2 diabetes were identified and a subcohort of 15,258 participants was selected for the case-cohort study. Country-specific HRs were estimated using Prentice-weighted Cox proportional hazards models and were pooled using a random effects meta-analysis. Eighteen other cohort studies were identified for the meta-analysis. Results: In the EPIC-InterAct Study, dietary fibre intake was associated with a lower risk of diabetes (HRQ4 vs Q1 0.82; 95% CI 0.69, 0.97) after adjustment for lifestyle and dietary factors. Similar inverse associations were observed for the intake of cereal fibre and vegetable fibre, but not fruit fibre. The associations were attenuated and no longer statistically significant after adjustment for BMI. In the meta-analysis (19 cohorts), the summary RRs per 10 g/day increase in intake were 0.91 (95% CI 0.87, 0.96) for total fibre, 0.75 (95% CI 0.65, 0.86) for cereal fibre, 0.95 (95% CI 0.87, 1.03) for fruit fibre and 0.93 (95% CI 0.82, 1.05) for vegetable fibre. Conclusions/interpretation: The overall evidence indicates that the intake of total and cereal fibre is inversely related to the risk of type 2 diabetes. The results of the EPIC-InterAct Study suggest that the association may be partially explained by body weight.",

keywords = "Case-cohort, Dietary fibre, EPIC-InterAct, Meta-analysis, Type 2 diabetes",

author = "Anneleen Kuijsten and Dagfinn Aune and Schulze, {Matthias B.} and Teresa Norat and {van Woudenbergh}, {Geertruida J.} and Beulens, {Joline W.J.} and Ivonne Sluijs and Spijkerman, {Annemieke M.W.} and {van der A}, {Daphne L.} and Domenico Palli and Tilman K{\"u}hn and Andrea Wendt and Brian Buijsse and Heiner Boeing and Valeria Pala and Pilar Amiano and Genevieve Buckland and {Huerta Casta{\~n}o}, {Jos{\'e} Mar{\'i}a} and Anne Tj{\o}nneland and Cecilie Kyr{\o} and Redondo, {Maria Luisa} and Carlotta Sacerdote and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Guy Fagherazzi and Beverley Balkau and Martin Lajous and Salvatore Panico and Franks, {Paul W.} and Olov Rolandsson and Peter Nilsson and Marju Orho-Melander and Kim Overvad and Inge Huybrechts and Nadia Slimani and Rosario Tumino and Aurelio Barricarte and Key, {Timothy J.} and Feskens, {Edith J.M.} and Claudia Langenberg and Stephen Sharp and Forouhi, {Nita G.} and Elio Riboli and Wareham, {Nicholas J.} and {The InterAct Consortium}",

note = "Funding Information: The InterAct project was supported by the European Union (LSHM-CT-2006-037197) in the Framework Programme 6; DA was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU); TN was supported by the World Cancer Research Fund (WCRF); JWJB and IS were supported by the Netherlands Agency grant IGE05012 and Incentive Grant from the Board of the UMC Utrecht; DLVDA and AMWS were supported by the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) and Statistics Netherlands; DP was supported by Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy; TK and AW were supported by the German Cancer Aid, German Cancer Research Center (DKFZ Heidelberg) and German Federal Ministry of Education and Research; PA was supported by the Regional Basque Country Government; GB was supported by The Spanish Ministry of Health (ISCIII RETICC RD06/0020/0091) and the Catalan Institute of Oncology; AT and CK were supported by the Danish Cancer Society; MLR was supported by the Government of the Principality of Asturias; SP was supported by Compagnia di San Paolo; PWF was supported by the Swedish Research Council, Novo Nordisk, Swedish Diabetes Association and Swedish Heart-Lung Foundation; OR was supported by the V{\"a}sterboten County Council; TJK was supported by the Cancer Research UK; NJW, SS, CL and NGF are supported by the Medical Research Council Epidemiology Unit MC_UU_12015/1 and MC_UU_12015/5. Publisher Copyright: {\textcopyright} 2015, The Author(s).",

year = "2015",

month = jul,

day = "20",

doi = "10.1007/s00125-015-3585-9",

language = "English",

volume = "58",

pages = "1394--1408",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "7",

}

TY - JOUR

T1 - Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies

AU - Kuijsten, Anneleen

AU - Aune, Dagfinn

AU - Schulze, Matthias B.

AU - Norat, Teresa

AU - van Woudenbergh, Geertruida J.

AU - Beulens, Joline W.J.

AU - Sluijs, Ivonne

AU - Spijkerman, Annemieke M.W.

AU - van der A, Daphne L.

AU - Palli, Domenico

AU - Kühn, Tilman

AU - Wendt, Andrea

AU - Buijsse, Brian

AU - Boeing, Heiner

AU - Pala, Valeria

AU - Amiano, Pilar

AU - Buckland, Genevieve

AU - Huerta Castaño, José María

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - Redondo, Maria Luisa

AU - Sacerdote, Carlotta

AU - Sánchez, María José

AU - Fagherazzi, Guy

AU - Balkau, Beverley

AU - Lajous, Martin

AU - Panico, Salvatore

AU - Franks, Paul W.

AU - Rolandsson, Olov

AU - Nilsson, Peter

AU - Orho-Melander, Marju

AU - Overvad, Kim

AU - Huybrechts, Inge

AU - Slimani, Nadia

AU - Tumino, Rosario

AU - Barricarte, Aurelio

AU - Key, Timothy J.

AU - Feskens, Edith J.M.

AU - Langenberg, Claudia

AU - Sharp, Stephen

AU - Forouhi, Nita G.

AU - Riboli, Elio

AU - Wareham, Nicholas J.

AU - The InterAct Consortium

N1 - Funding Information: The InterAct project was supported by the European Union (LSHM-CT-2006-037197) in the Framework Programme 6; DA was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU); TN was supported by the World Cancer Research Fund (WCRF); JWJB and IS were supported by the Netherlands Agency grant IGE05012 and Incentive Grant from the Board of the UMC Utrecht; DLVDA and AMWS were supported by the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) and Statistics Netherlands; DP was supported by Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy; TK and AW were supported by the German Cancer Aid, German Cancer Research Center (DKFZ Heidelberg) and German Federal Ministry of Education and Research; PA was supported by the Regional Basque Country Government; GB was supported by The Spanish Ministry of Health (ISCIII RETICC RD06/0020/0091) and the Catalan Institute of Oncology; AT and CK were supported by the Danish Cancer Society; MLR was supported by the Government of the Principality of Asturias; SP was supported by Compagnia di San Paolo; PWF was supported by the Swedish Research Council, Novo Nordisk, Swedish Diabetes Association and Swedish Heart-Lung Foundation; OR was supported by the Västerboten County Council; TJK was supported by the Cancer Research UK; NJW, SS, CL and NGF are supported by the Medical Research Council Epidemiology Unit MC_UU_12015/1 and MC_UU_12015/5. Publisher Copyright: © 2015, The Author(s).

PY - 2015/7/20

Y1 - 2015/7/20

N2 - Aims/hypothesis: Intake of dietary fibre has been associated with a reduced risk of type 2 diabetes, but few European studies have been published on this. We evaluated the association between intake of dietary fibre and type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study and in a meta-analysis of prospective studies. Methods: During 10.8 years of follow-up, 11,559 participants with type 2 diabetes were identified and a subcohort of 15,258 participants was selected for the case-cohort study. Country-specific HRs were estimated using Prentice-weighted Cox proportional hazards models and were pooled using a random effects meta-analysis. Eighteen other cohort studies were identified for the meta-analysis. Results: In the EPIC-InterAct Study, dietary fibre intake was associated with a lower risk of diabetes (HRQ4 vs Q1 0.82; 95% CI 0.69, 0.97) after adjustment for lifestyle and dietary factors. Similar inverse associations were observed for the intake of cereal fibre and vegetable fibre, but not fruit fibre. The associations were attenuated and no longer statistically significant after adjustment for BMI. In the meta-analysis (19 cohorts), the summary RRs per 10 g/day increase in intake were 0.91 (95% CI 0.87, 0.96) for total fibre, 0.75 (95% CI 0.65, 0.86) for cereal fibre, 0.95 (95% CI 0.87, 1.03) for fruit fibre and 0.93 (95% CI 0.82, 1.05) for vegetable fibre. Conclusions/interpretation: The overall evidence indicates that the intake of total and cereal fibre is inversely related to the risk of type 2 diabetes. The results of the EPIC-InterAct Study suggest that the association may be partially explained by body weight.

AB - Aims/hypothesis: Intake of dietary fibre has been associated with a reduced risk of type 2 diabetes, but few European studies have been published on this. We evaluated the association between intake of dietary fibre and type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study and in a meta-analysis of prospective studies. Methods: During 10.8 years of follow-up, 11,559 participants with type 2 diabetes were identified and a subcohort of 15,258 participants was selected for the case-cohort study. Country-specific HRs were estimated using Prentice-weighted Cox proportional hazards models and were pooled using a random effects meta-analysis. Eighteen other cohort studies were identified for the meta-analysis. Results: In the EPIC-InterAct Study, dietary fibre intake was associated with a lower risk of diabetes (HRQ4 vs Q1 0.82; 95% CI 0.69, 0.97) after adjustment for lifestyle and dietary factors. Similar inverse associations were observed for the intake of cereal fibre and vegetable fibre, but not fruit fibre. The associations were attenuated and no longer statistically significant after adjustment for BMI. In the meta-analysis (19 cohorts), the summary RRs per 10 g/day increase in intake were 0.91 (95% CI 0.87, 0.96) for total fibre, 0.75 (95% CI 0.65, 0.86) for cereal fibre, 0.95 (95% CI 0.87, 1.03) for fruit fibre and 0.93 (95% CI 0.82, 1.05) for vegetable fibre. Conclusions/interpretation: The overall evidence indicates that the intake of total and cereal fibre is inversely related to the risk of type 2 diabetes. The results of the EPIC-InterAct Study suggest that the association may be partially explained by body weight.

KW - Case-cohort

KW - Dietary fibre

KW - EPIC-InterAct

KW - Meta-analysis

KW - Type 2 diabetes

U2 - 10.1007/s00125-015-3585-9

DO - 10.1007/s00125-015-3585-9

M3 - Article

C2 - 26021487

AN - SCOPUS:84931577299

SN - 0012-186X

VL - 58

SP - 1394

EP - 1408

JO - Diabetologia

JF - Diabetologia

IS - 7

ER -

Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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