TY - JOUR
T1 - Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition
AU - Park, Jin Young
AU - Bueno-de-Mesquita, H Bas
AU - Ferrari, Pietro
AU - Weiderpass, Elisabete
AU - de Batlle, Jordi
AU - Tjønneland, Anne
AU - Kyro, Cecilie
AU - Rebours, Vinciane
AU - Boutron-Ruault, Marie-Christine
AU - Mancini, Francesca Romana
AU - Katzke, Verena
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - La Vecchia, Carlo
AU - Kritikou, Maria
AU - Masala, Giovanna
AU - Pala, Valeria
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Peeters, Petra H
AU - Skeie, Guri
AU - Merino, Susana
AU - Duell, Eric J
AU - Rodríguez-Barranco, Miguel
AU - Dorronsoro, Miren
AU - Chirlaque, Maria-Dolores
AU - Ardanaz, Eva
AU - Gylling, Björn
AU - Schneede, Jörn
AU - Ericson, Ulrika
AU - Sternby, Hanna
AU - Khaw, Kay-Tee
AU - Bradbury, Kathryn E
AU - Huybrechts, Inge
AU - Aune, Dagfinn
AU - Vineis, Paolo
AU - Slimani, Nadia
N1 - © 2018 UICC.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, ptrend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
AB - Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, ptrend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
KW - Adult
KW - Europe/epidemiology
KW - Female
KW - Folic Acid/administration & dosage
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Nutritional Status
KW - Pancreatic Neoplasms/epidemiology
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Self Report
KW - Smoking/adverse effects
U2 - 10.1002/ijc.31830
DO - 10.1002/ijc.31830
M3 - Article
C2 - 30178496
VL - 144
SP - 1511
EP - 1521
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 7
ER -