TY - JOUR
T1 - Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
AU - Zamora-Ros, Raul
AU - Cayssials, Valerie
AU - Jenab, Mazda
AU - Rothwell, Joseph A
AU - Fedirko, Veronika
AU - Aleksandrova, Krasimira
AU - Tjønneland, Anne
AU - Kyrø, Cecilie
AU - Overvad, Kim
AU - Boutron-Ruault, Marie-Christine
AU - Carbonnel, Franck
AU - Mahamat-Saleh, Yahya
AU - Kaaks, Rudolf
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Valanou, Elissavet
AU - Vasilopoulou, Effie
AU - Masala, Giovanna
AU - Pala, Valeria
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Ricceri, Fulvio
AU - Weiderpass, Elisabete
AU - Lukic, Marko
AU - Sandanger, Torkjel M
AU - Lasheras, Cristina
AU - Agudo, Antonio
AU - Sánchez, Maria-Jose
AU - Amiano, Pilar
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Sonestedt, Emily
AU - Ohlsson, Bodil
AU - Nilsson, Lena Maria
AU - Rutegård, Martin
AU - Bueno-de-Mesquita, Bas
AU - Peeters, Petra H
AU - Khaw, Kay-Thee
AU - Wareham, Nicholas J
AU - Bradbury, Kathryn
AU - Freisling, Heinz
AU - Romieu, Isabelle
AU - Cross, Amanda J
AU - Vineis, Paolo
AU - Scalbert, Augustin
PY - 2018/5/15
Y1 - 2018/5/15
N2 - Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
AB - Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
KW - Adult
KW - Aged
KW - Coffee/chemistry
KW - Cohort Studies
KW - Colorectal Neoplasms/epidemiology
KW - Europe/epidemiology
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Nutrition Assessment
KW - Polyphenols/administration & dosage
KW - Prospective Studies
KW - Surveys and Questionnaires
KW - Tea/chemistry
U2 - 10.1007/s10654-018-0408-6
DO - 10.1007/s10654-018-0408-6
M3 - Article
C2 - 29761424
SN - 0393-2990
VL - 33
SP - 1063
EP - 1075
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 11
ER -
