Dietary patterns and chronic kidney disease: a cross-sectional association in the Irish Nun Eye Study

Euan Paterson, Charlotte Neville, Giuliana Silvestri, Shannon Montgomery, Evelyn Moore, Vittorio Silvestri, Christopher Cardwell, Tom J MacGillivray, Alexander Maxwell, Jayne Woodside, Gareth McKay

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Abstract

Associations between dietary patterns and chronic kidney disease are not well established, especially in European populations. We conducted a cross-sectional study of 1033 older Irish women (age range 56–100 years) with a restricted lifestyle. Dietary intake was assessed using a food frequency questionnaire. Renal function was determined by estimated glomerular filtration rate. Two dietary patterns were identified within the study population using factor analysis. A significant negative association was found between unhealthy dietary pattern adherence and renal function in both unadjusted and adjusted models controlling for potential confounding variables (p for trend <0.001), with a mean difference in estimated glomerular filtration rate of −6 ml/min/1.73 m2 between those in the highest fifth of adherence to the unhealthy dietary pattern compared to the lowest, in the fully adjusted model. Chronic kidney disease risk was significantly greater for the highest fifth, compared to the lowest fifth of unhealthy dietary pattern adherence in adjusted models (adjusted odds ratio = 2.62, p < 0.001). Adherence to the healthy dietary pattern was not associated with renal function or chronic kidney disease in adjusted models. In this cohort, an unhealthy dietary pattern was associated with lower renal function and greater prevalence of chronic kidney disease.
Original languageEnglish
JournalScientific Reports
DOIs
Publication statusPublished - 27 Apr 2018

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Chronic Renal Insufficiency
Kidney
Glomerular Filtration Rate
Confounding Factors (Epidemiology)
Population
Statistical Factor Analysis
Life Style
Cross-Sectional Studies
Odds Ratio
Food
Nuns

Cite this

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title = "Dietary patterns and chronic kidney disease: a cross-sectional association in the Irish Nun Eye Study",
abstract = "Associations between dietary patterns and chronic kidney disease are not well established, especially in European populations. We conducted a cross-sectional study of 1033 older Irish women (age range 56–100 years) with a restricted lifestyle. Dietary intake was assessed using a food frequency questionnaire. Renal function was determined by estimated glomerular filtration rate. Two dietary patterns were identified within the study population using factor analysis. A significant negative association was found between unhealthy dietary pattern adherence and renal function in both unadjusted and adjusted models controlling for potential confounding variables (p for trend <0.001), with a mean difference in estimated glomerular filtration rate of −6 ml/min/1.73 m2 between those in the highest fifth of adherence to the unhealthy dietary pattern compared to the lowest, in the fully adjusted model. Chronic kidney disease risk was significantly greater for the highest fifth, compared to the lowest fifth of unhealthy dietary pattern adherence in adjusted models (adjusted odds ratio = 2.62, p < 0.001). Adherence to the healthy dietary pattern was not associated with renal function or chronic kidney disease in adjusted models. In this cohort, an unhealthy dietary pattern was associated with lower renal function and greater prevalence of chronic kidney disease.",
author = "Euan Paterson and Charlotte Neville and Giuliana Silvestri and Shannon Montgomery and Evelyn Moore and Vittorio Silvestri and Christopher Cardwell and MacGillivray, {Tom J} and Alexander Maxwell and Jayne Woodside and Gareth McKay",
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Dietary patterns and chronic kidney disease: a cross-sectional association in the Irish Nun Eye Study. / Paterson, Euan; Neville, Charlotte; Silvestri, Giuliana; Montgomery, Shannon; Moore, Evelyn; Silvestri, Vittorio; Cardwell, Christopher; MacGillivray, Tom J; Maxwell, Alexander; Woodside, Jayne; McKay, Gareth.

In: Scientific Reports, 27.04.2018.

Research output: Contribution to journalArticle

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T1 - Dietary patterns and chronic kidney disease: a cross-sectional association in the Irish Nun Eye Study

AU - Paterson, Euan

AU - Neville, Charlotte

AU - Silvestri, Giuliana

AU - Montgomery, Shannon

AU - Moore, Evelyn

AU - Silvestri, Vittorio

AU - Cardwell, Christopher

AU - MacGillivray, Tom J

AU - Maxwell, Alexander

AU - Woodside, Jayne

AU - McKay, Gareth

PY - 2018/4/27

Y1 - 2018/4/27

N2 - Associations between dietary patterns and chronic kidney disease are not well established, especially in European populations. We conducted a cross-sectional study of 1033 older Irish women (age range 56–100 years) with a restricted lifestyle. Dietary intake was assessed using a food frequency questionnaire. Renal function was determined by estimated glomerular filtration rate. Two dietary patterns were identified within the study population using factor analysis. A significant negative association was found between unhealthy dietary pattern adherence and renal function in both unadjusted and adjusted models controlling for potential confounding variables (p for trend <0.001), with a mean difference in estimated glomerular filtration rate of −6 ml/min/1.73 m2 between those in the highest fifth of adherence to the unhealthy dietary pattern compared to the lowest, in the fully adjusted model. Chronic kidney disease risk was significantly greater for the highest fifth, compared to the lowest fifth of unhealthy dietary pattern adherence in adjusted models (adjusted odds ratio = 2.62, p < 0.001). Adherence to the healthy dietary pattern was not associated with renal function or chronic kidney disease in adjusted models. In this cohort, an unhealthy dietary pattern was associated with lower renal function and greater prevalence of chronic kidney disease.

AB - Associations between dietary patterns and chronic kidney disease are not well established, especially in European populations. We conducted a cross-sectional study of 1033 older Irish women (age range 56–100 years) with a restricted lifestyle. Dietary intake was assessed using a food frequency questionnaire. Renal function was determined by estimated glomerular filtration rate. Two dietary patterns were identified within the study population using factor analysis. A significant negative association was found between unhealthy dietary pattern adherence and renal function in both unadjusted and adjusted models controlling for potential confounding variables (p for trend <0.001), with a mean difference in estimated glomerular filtration rate of −6 ml/min/1.73 m2 between those in the highest fifth of adherence to the unhealthy dietary pattern compared to the lowest, in the fully adjusted model. Chronic kidney disease risk was significantly greater for the highest fifth, compared to the lowest fifth of unhealthy dietary pattern adherence in adjusted models (adjusted odds ratio = 2.62, p < 0.001). Adherence to the healthy dietary pattern was not associated with renal function or chronic kidney disease in adjusted models. In this cohort, an unhealthy dietary pattern was associated with lower renal function and greater prevalence of chronic kidney disease.

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