Differences in genomic architecture between two distinct geographical strains of the blood fluke Schistosoma japonicum reveal potential phenotype basis

Geoffrey N. Gobert*, Hong You, Malcolm K. Jones, Russell McInnes, Donald P. McManus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The Chinese (SjC) and Philippine (SjP) strains of the blood fluke Schistosoma japonicum have been shown to present clearly different phenotypes in fecundity, pathology, drug sensitivity and immunology. We used microarray based comparative genomic hybridisation (aCGH) to investigate structural differences in the genomes of the two strains and identified seven distinct regions of the S. japonicum genome that present differential aCGH representing either deletion or duplication regions in SjP. Within these regions, genes predicted to be associated with the recognised phenotypic differences were identified and that may provide new insights into the biology and evolution of the two strains, with implications for the epidemiology and control of schistosomiasis japonica in China and the Philippines.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalMolecular and Cellular Probes
Volume27
Issue number1
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

Keywords

  • Comparative genomics
  • Microarray
  • Schistosoma

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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