Direct aerobic oxidation of monoalcohol and diols to acetals using tandem Ru@MOF catalysts

Songwei Zhang, Jerry Pui Ho Li, Jingpeng Zhao, Dan Wu, Biao Yuan, Willinton Yesid Hernández, Wen-Juan Zhou, Tao He, Yi Yu, Yong Yang*, Vitaly Ordomsky*, Tao Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The aerobic oxidation of monoalcohols and diols to acetals is an important academic and industrial challenge for the production of fine chemicals and intermediates. The existing methods usually rely on a two-step process in which alcohols are first oxidized to aldehydes over metal catalysts (Ru, Pt, Pd) and then acetalized using acids. Due to the instability of aldehydes, how to avoid over-oxidation to their respective carboxylic acids and esters is a long-standing challenge. For this reason, certain non-conjugated dialdehydes have never been successfully produced from diol oxidation. Hereby we report a Ru@metal-organic framework (MOF) tandem catalyst containing ultra-fine Ru nanoparticles (< 2 nm) for direct alcohol to acetal conversion of monoalcohol and diols with no formation of carboxylic acids. Mechanistic study reveals that the presence of Lewis acid sites in the MOF work in concert with Ru active sites to promptly convert aldehydes to acetals thereby effectively suppressing the formation of over-oxidation byproducts.
Original languageEnglish
Number of pages7
JournalNano Research
Publication statusPublished - 13 Mar 2020


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