Disruption of the gene regulatory programme in neurodevelopmental disorders

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Cortical development consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear that gene expression programs governing these events rely on the interplay between signalling molecules, transcription factors and epigenetic mechanisms. When genetic or environmental factors disrupt expression of genes involved in important brain development processes, neurodevelopmental disorders can occur. This review aims to highlight how recent advances in technologies have helped uncover and imitate the gene regulatory mechanisms commonly disrupted in neurodevelopmental disorders.
Original languageEnglish
Article number194860
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Issue number7
Early online date20 Sep 2022
Publication statusPublished - Oct 2022


  • Epigenetics
  • Genomics
  • Gene regulation
  • Cortical development
  • Neurodevelopmental disorders


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