Disruption of the gene regulatory programme in neurodevelopmental disorders

Aoife Griffin; Arun Mahesh; Vijay K Tiwari

doi:10.1016/j.bbagrm.2022.194860

Disruption of the gene regulatory programme in neurodevelopmental disorders

Aoife Griffin, Arun Mahesh, Vijay K Tiwari

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Cortical development consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. It is becoming clear that gene expression programs governing these events rely on the interplay between signalling molecules, transcription factors and epigenetic mechanisms. When genetic or environmental factors disrupt expression of genes involved in important brain development processes, neurodevelopmental disorders can occur. This review aims to highlight how recent advances in technologies have helped uncover and imitate the gene regulatory mechanisms commonly disrupted in neurodevelopmental disorders.

Original language	English
Article number	194860
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1865
Issue number	7
Early online date	20 Sep 2022
DOIs	https://doi.org/10.1016/j.bbagrm.2022.194860
Publication status	Published - Oct 2022

Keywords

Epigenetics
Genomics
Gene regulation
Cortical development
Neurodevelopmental disorders

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10.1016/j.bbagrm.2022.194860Licence: CC BY

Disruption of the gene regulatory programme in neurodevelopmental disorders
Copyright 2022 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 3.28 MBLicence: CC BY

Cite this

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Disruption of the gene regulatory programme in neurodevelopmental disorders

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Keywords

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