The prevalence of life-threatening, drug resistant microbial infections has challenged researchers to consider alternatives to currently available antibiotics. Teixobactin is a recently discovered “resistance proof” antimicrobial peptide that targets the bacterial cell wall precursor lipid II. In doing so, teixobactin exhibits potent antimicrobial activityagainst a wide range of Gram-positive organisms. Here we demonstrate that teixobactin and several structural analogues are capable of binding lipid II from both Gram-positive and Gram-negative bacteria. Furthermore, we show that when combined with known outer membrane-disrupting peptides, teixobactin is active against Gram-negative organisms.
|Number of pages||6|
|Early online date||24 Sep 2019|
|Publication status||Early online date - 24 Sep 2019|
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The synthesis and studies of type II porous liquidsAuthor: Alexander, F., Jul 2022
Supervisor: James, S. (Supervisor) & De Silva, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy