Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II

Sorina Chiorean, Isaac Antwi, Daniel Carney, Ioli Kotsogianni, Andrew Giltrap, Francesca M. Alexander, Stephen A. Cochrane, Richard Payne, Nathaniel Martin, Antoine Henninot, John Vederas

Research output: Contribution to journalArticle

Abstract

The prevalence of life-threatening, drug resistant microbial infections has challenged researchers to consider alternatives to currently available antibiotics. Teixobactin is a recently discovered “resistance proof” antimicrobial peptide that targets the bacterial cell wall precursor lipid II. In doing so, teixobactin exhibits potent antimicrobial activityagainst a wide range of Gram-positive organisms. Here we demonstrate that teixobactin and several structural analogues are capable of binding lipid II from both Gram-positive and Gram-negative bacteria. Furthermore, we show that when combined with known outer membrane-disrupting peptides, teixobactin is active against Gram-negative organisms.
Original languageEnglish
Number of pages6
JournalChemBioChem
Early online date24 Sep 2019
DOIs
Publication statusEarly online date - 24 Sep 2019

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Cell Wall
Cells
Peptides
Gram-Negative Bacteria
Bacteria
Research Personnel
Anti-Bacterial Agents
Membranes
teixobactin
muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol
Infection
Pharmaceutical Preparations

Cite this

Chiorean, Sorina ; Antwi, Isaac ; Carney, Daniel ; Kotsogianni, Ioli ; Giltrap, Andrew ; Alexander, Francesca M. ; Cochrane, Stephen A. ; Payne, Richard ; Martin, Nathaniel ; Henninot, Antoine ; Vederas, John. / Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II. In: ChemBioChem. 2019.
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Chiorean, S, Antwi, I, Carney, D, Kotsogianni, I, Giltrap, A, Alexander, FM, Cochrane, SA, Payne, R, Martin, N, Henninot, A & Vederas, J 2019, 'Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II', ChemBioChem. https://doi.org/10.1002/cbic.201900504

Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II. / Chiorean, Sorina; Antwi, Isaac; Carney, Daniel; Kotsogianni, Ioli; Giltrap, Andrew; Alexander, Francesca M.; Cochrane, Stephen A.; Payne, Richard; Martin, Nathaniel; Henninot, Antoine; Vederas, John.

In: ChemBioChem, 24.09.2019.

Research output: Contribution to journalArticle

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