Diverse pathogenicity of Burkholderia cepacia complex strains in the Caenorhabditis elegans host model

Silvia T Cardona, Julia Wopperer, Leo Eberl, Miguel A Valvano

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A fast screening method was developed to assess the pathogenicity of a diverse collection of environmental and clinical Burkholderia cepacia complex isolates in the nematode Caenorhabditis elegans. The method was validated by comparison with the standard slow-killing assay. We observed that the pathogenicity of B. cepacia complex isolates in C. elegans was strain-dependent but species-independent. The wide range of observed pathogenic phenotypes agrees with the high degree of phenotypic variation among species of the B. cepacia complex and suggests that the taxonomic classification of a given strain within the complex cannot predict pathogenicity.
Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalFEMS Microbiology Letters
Volume250
Issue number1
DOIs
Publication statusPublished - 01 Sep 2005

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

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