DNA Reorientation on Au Nanoparticles: Label-Free Detection of Hybridization by Surface Enhanced Raman Spectroscopy

Evanthia Papadopoulou, Steven E J Bell

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.

Original languageEnglish
Pages (from-to)10966-10968
Number of pages3
JournalChemical Communications
Volume47
Issue number39
DOIs
Publication statusPublished - 21 Oct 2011

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

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