DNA Reorientation on Au Nanoparticles: Label-Free Detection of Hybridization by Surface Enhanced Raman Spectroscopy

Evanthia Papadopoulou; Steven E J Bell

doi:10.1039/c1cc13705k

DNA Reorientation on Au Nanoparticles: Label-Free Detection of Hybridization by Surface Enhanced Raman Spectroscopy

Evanthia Papadopoulou
, Steven E J Bell

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.

Original language	English
Pages (from-to)	10966-10968
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	39
DOIs	https://doi.org/10.1039/c1cc13705k
Publication status	Published - 21 Oct 2011

ASJC Scopus subject areas

Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Catalysis
General Chemistry

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10.1039/c1cc13705k

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title = "DNA Reorientation on Au Nanoparticles: Label-Free Detection of Hybridization by Surface Enhanced Raman Spectroscopy",

abstract = "DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.",

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AU - Papadopoulou, Evanthia

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Y1 - 2011/10/21

N2 - DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.

AB - DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.

U2 - 10.1039/c1cc13705k

DO - 10.1039/c1cc13705k

M3 - Article

C2 - 21909525

SN - 1359-7345

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SP - 10966

EP - 10968

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

DNA Reorientation on Au Nanoparticles: Label-Free Detection of Hybridization by Surface Enhanced Raman Spectroscopy

Abstract

ASJC Scopus subject areas

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