Do Serum Streptococcus utans antibody levels predict all-cause mortality?

Mary McClory, Gerard Linden, Fionnuala Lundy, Ikhlas El Karim

Research output: Contribution to journalMeeting abstractpeer-review

Abstract

Objectives: To determine if the level of serum antibodies to Streptococcus mutans is associated with all-cause mortality in a prospective study of a cohort of men in Northern Ireland.
Methods: A representative sample of 999 dentate men, aged between 58 and 72 years, had serum samples taken between 2001 and 2003. An ELISA-based method was used to determine the levels of IgG antibodies towards S. mutans. The primary end point was death from any cause and this data was available from the Business Service Organisation, Northern Ireland up to July 2021. Cross sectional analysis was performed using the independent t-test and Cox’s proportional hazards model was used to calculate Hazard Ratios (HR) and 95% CI.
Results: The mean age of the 999 men in the study at baseline was 64.2 (SD 2.9) years. Over 16.5 years follow up 379 (37.9%) of the men died. Cox’s hazard proportion analysis revealed that S. mutans was a significant predictor of all-cause mortality in the fully adjusted model (HR=1.35, (1.05-1.72) p=0.02). Confounders adjusted for included age, body-mass-index, smoking status, number of teeth, logE mean attachment loss as a measure of periodontal disease and a measure of socio-economic status.
Conclusions: There was evidence in the Western European men studied that those with high levels of serum antibodies to Streptococcus mutans had a significantly increased risk of all-cause mortality.
Original languageEnglish
JournalJournal of Dental Research
Publication statusPublished - 21 Jun 2023
Event2023 IADR/LAR General Session with WCPD -
Duration: 21 Jun 202324 Jun 2023

Fingerprint

Dive into the research topics of 'Do Serum Streptococcus utans antibody levels predict all-cause mortality?'. Together they form a unique fingerprint.

Cite this