Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid

Sinéad M Weldon; Anne C Mullen; Christine E Loscher; Lisa A Hurley; Helen M Roche

doi:10.1016/j.jnutbio.2006.04.003

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid

Sinéad M Weldon
, Anne C Mullen
, Christine E Loscher
, Lisa A Hurley
, Helen M Roche

Research output: Contribution to journal › Article › peer-review

286 Citations (Scopus)

Abstract

A number of studies have investigated the effects of fish oil on the production of pro-inflammatory cytokines using peripheral blood mononuclear cell models. The majority of these studies have employed heterogeneous blends of long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which preclude examination of the individual effects of LC n-3 PUFA. This study investigated the differential effects of pure EPA and DHA on cytokine expression and nuclear factor kappaB (NF-kappaB) activation in human THP-1 monocyte-derived macrophages. Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P

Original language	English
Pages (from-to)	250-8
Journal	The Journal of nutritional biochemistry
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.jnutbio.2006.04.003
Publication status	Published - Apr 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Endocrinology, Diabetes and Metabolism

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10.1016/j.jnutbio.2006.04.003

Cite this

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title = "Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid",

abstract = "A number of studies have investigated the effects of fish oil on the production of pro-inflammatory cytokines using peripheral blood mononuclear cell models. The majority of these studies have employed heterogeneous blends of long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which preclude examination of the individual effects of LC n-3 PUFA. This study investigated the differential effects of pure EPA and DHA on cytokine expression and nuclear factor kappaB (NF-kappaB) activation in human THP-1 monocyte-derived macrophages. Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P",

author = "Weldon, \{Sin{\'e}ad M\} and Mullen, \{Anne C\} and Loscher, \{Christine E\} and Hurley, \{Lisa A\} and Roche, \{Helen M\}",

year = "2007",

month = apr,

doi = "10.1016/j.jnutbio.2006.04.003",

language = "English",

volume = "18",

pages = "250--8",

journal = "The Journal of nutritional biochemistry",

issn = "0955-2863",

publisher = "Elsevier Inc.",

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}

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. / Weldon, Sinéad M; Mullen, Anne C; Loscher, Christine E et al.
In: The Journal of nutritional biochemistry, Vol. 18, No. 4, 04.2007, p. 250-8.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid

AU - Weldon, Sinéad M

AU - Mullen, Anne C

AU - Loscher, Christine E

AU - Hurley, Lisa A

AU - Roche, Helen M

PY - 2007/4

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AB - A number of studies have investigated the effects of fish oil on the production of pro-inflammatory cytokines using peripheral blood mononuclear cell models. The majority of these studies have employed heterogeneous blends of long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which preclude examination of the individual effects of LC n-3 PUFA. This study investigated the differential effects of pure EPA and DHA on cytokine expression and nuclear factor kappaB (NF-kappaB) activation in human THP-1 monocyte-derived macrophages. Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P

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DO - 10.1016/j.jnutbio.2006.04.003

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SN - 0955-2863

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SP - 250

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JO - The Journal of nutritional biochemistry

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IS - 4

ER -

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid

Abstract

UN SDGs

ASJC Scopus subject areas

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