A one-pot isomerization–Claisen protocol has been developed for the synthesis of highly substituted allylsilanes. Monosilylated divinyl ethers can be isomerized using a cationic iridium(I) catalyst followed by a thermal Claisen rearrangement to provide the allylsilanes in excellent yields and diastereoselectivities.
ASJC Scopus subject areas
- Organic Chemistry
Cook, M., & McLaughlin, M. (2012). Domino Alkene-Isomerization–Claisen Rearrangement Strategy to Substituted Allylsilanes. Journal of Organic Chemistry, 77(4), 2058-2063. https://doi.org/10.1021/jo202560g